Marsh W L
Mayo Clin Proc. 1977 Mar;52(3):145-9.
Blood group genes are inherited in a straightforward manner and their products are readily detectable. Because of this they are utilized over a wide area of scientific endeavor and provide excellent markers for use in gene mapping of the human chromosomes. Both the Rh and Duffy blood group genes have now been localized to the number 1 chromosome. Studies of a patient whose red cells exhibit mosaicism for the Rh blood group indicate that loss of the end of the short arm of chromosome number 1 is associated with loss of an Rh gene complex. The Rh gene can, therefore, be assigned with some precision to this region of the chromosome.
血型基因以一种直接的方式遗传，其产物易于检测。因此，它们在广泛的科学研究领域中得到应用，并为人类染色体基因图谱绘制提供了优良的标记。Rh和达菲血型基因现已定位到第1号染色体上。对一名红细胞表现出Rh血型嵌合体的患者的研究表明，1号染色体短臂末端的缺失与Rh基因复合体的缺失有关。因此，Rh基因可以较为精确地定位到该染色体区域。
