Heck H D, Casanova-Schmitz M, Dodd P B, Schachter E N, Witek T J, Tosun T
Am Ind Hyg Assoc J. 1985 Jan;46(1):1-3. doi: 10.1080/15298668591394275.
The effect of exposure to formaldehyde (CH2O) on the CH2O concentration of the blood was determined. Eight male F-344 rats were exposed to 14.4 +/- 2.4 ppm of CH2O for 2 hours and the blood was collected immediately after exposure. Formaldehyde concentrations in the blood were determined by gas chromatography/mass spectrometry. The blood of eight rats unexposed to CH2O was collected and analyzed in the same manner. Measured CH2O concentrations (micrograms/g of blood) were: controls, 2.24 +/- 0.07; exposed, 2.25 +/- 0.07 (mean +/- S.E.). Formaldehyde concentrations in human blood were determined by analyzing samples of venous blood collected before and after exposure of six human volunteers (4 M, 2 F) to 1.9 +/- 0.1 ppm of CH2O for 40 min. Average CH2O concentrations (micrograms/g of blood) were: before exposure, 2.61 +/- 0.14; after exposure, 2.77 +/- 0.28. In neither experiment was there a statistically significant effect of exposure on the average CH2O concentration of the blood. However, human subjects differed significantly with respect to their blood CH2O concentrations, and significant differences (either an increase or a decrease) were found between the CH2O concentrations of the blood taken before and after exposure from some of the subjects, suggesting that blood CH2O concentrations may vary with time.
测定了接触甲醛（CH₂O）对血液中CH₂O浓度的影响。将八只雄性F - 344大鼠暴露于14.4±2.4 ppm的CH₂O中2小时，暴露后立即采集血液。通过气相色谱/质谱法测定血液中的甲醛浓度。以相同方式采集并分析八只未接触CH₂O的大鼠的血液。测得的CH₂O浓度（微克/克血液）为：对照组，2.24±0.07；暴露组，2.25±0.07（平均值±标准误）。通过分析六名人类志愿者（4名男性，2名女性）在接触1.9±0.1 ppm的CH₂O 40分钟前后采集的静脉血样本，测定人血中的甲醛浓度。平均CH₂O浓度（微克/克血液）为：接触前，2.61±0.14；接触后，2.77±0.28。在这两个实验中，接触均未对血液中平均CH₂O浓度产生统计学上的显著影响。然而，人类受试者的血液CH₂O浓度存在显著差异，并且在一些受试者接触前后采集的血液CH₂O浓度之间发现了显著差异（升高或降低），这表明血液CH₂O浓度可能随时间变化。
