Cushnie Adriana K, Bush Nicholas J, Sevel Landrew S, Stennett-Blackmon Bethany, Farone Allie, Nixon Sara Jo, Robinson Michael E, Boissoneault Jeff
Department of Anesthesiology, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Alcohol Clin Exp Res (Hoboken). 2025 Jun;49(6):1221-1232. doi: 10.1111/acer.70053. Epub 2025 Apr 19.
BACKGROUND: The insular cortex (IC), which includes anterior (AIC) and posterior (PIC) subdivisions, plays a role in numerous functions and behaviors, including chronic alcohol consumption. This study investigated acute alcohol effects on functional connectivity (FC) of the IC in healthy social drinkers. We hypothesized that acute alcohol consumption would significantly disrupt IC resting-state FC (rsFC) with the whole brain and would differentially modulate the rsFC of the AIC and PIC. This study also examined the association of alcohol-induced changes in IC rsFC with subjective intoxication and whether sex and family history of alcohol problems moderate the effect of acute alcohol intake on IC rsFC. METHODS: One hundred and seven healthy social drinkers (25-45 years) completed two counterbalanced laboratory sessions where they consumed either a placebo or alcohol-containing beverage (target breath alcohol concentration 0.08 g/dL), followed by a 9-min resting-state functional magnetic resonance imaging scan. Subjective intoxication was assessed using a visual analog scale from "not at all intoxicated" to "most intoxicated imaginable." Effects of alcohol on IC connectivity were assessed using the CONN toolbox with IC regions of interest (ROIs) defined using the atlas of intrinsic connectivity of homotopic areas (AICHA). RESULTS: Alcohol intake resulted in widespread changes in rsFC of the IC with other brain regions, including increased rsFC with nodes of the salience network. Alcohol also attenuated differences in rsFC between the AIC and PIC compared with placebo. Sex and family history of alcohol problems did not significantly moderate these effects. CONCLUSIONS: Acute alcohol intake altered the rsFC of the IC and its connections to numerous structures. Consistent with prior evidence that alcohol disrupts the brain's functional organization, alcohol intake tended to attenuate differences in the connectivity profiles of AIC and PIC. Additional research is needed to determine how these effects may underlie alcohol's broader neurobehavioral consequences.
背景：岛叶皮质（IC）包括前岛叶（AIC）和后岛叶（PIC）亚区，在包括长期饮酒在内的多种功能和行为中发挥作用。本研究调查了急性酒精摄入对健康社交饮酒者岛叶皮质功能连接（FC）的影响。我们假设，急性酒精摄入会显著破坏岛叶皮质与全脑的静息态功能连接（rsFC），并对前岛叶和后岛叶的rsFC产生不同的调节作用。本研究还考察了酒精引起的岛叶皮质rsFC变化与主观醉酒感之间的关联，以及性别和酒精问题家族史是否会调节急性酒精摄入对岛叶皮质rsFC的影响。 方法：107名健康社交饮酒者（年龄25 - 45岁）完成了两个平衡的实验室环节，他们分别饮用了安慰剂或含酒精饮料（目标呼气酒精浓度为0.08 g/dL），随后进行9分钟的静息态功能磁共振成像扫描。使用从“完全未醉酒”到“想象中最醉酒”的视觉模拟量表评估主观醉酒感。使用CONN工具箱评估酒精对岛叶皮质连接性的影响，岛叶皮质感兴趣区域（ROI）使用同型区域内在连接图谱（AICHA）进行定义。 结果：酒精摄入导致岛叶皮质与其他脑区的rsFC发生广泛变化，包括与突显网络节点的rsFC增加。与安慰剂相比，酒精还减弱了前岛叶和后岛叶之间rsFC的差异。性别和酒精问题家族史并未显著调节这些影响。 结论：急性酒精摄入改变了岛叶皮质的rsFC及其与众多结构的连接。与先前酒精破坏大脑功能组织的证据一致，酒精摄入倾向于减弱前岛叶和后岛叶连接模式的差异。需要进一步的研究来确定这些影响如何构成酒精更广泛的神经行为后果的基础。
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