Torres-Tenor Juan Luis, Bruera Eduardo, Sánchez-Mañas Inés, Pérez-Manrique Teresa, Castellano-Candalija Aránzazu, Alonso-Babarro Alberto
Department of Palliative Care, La Paz Hospital, Paseo de La Castellana 261, 28046, Madrid, Spain.
Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer, Houston, TX, USA.
Clin Transl Oncol. 2025 Apr 19. doi: 10.1007/s12094-025-03929-7.
To assess non-medical opioid use (NMOU) risk frequency in outpatients with cancer, compare at-risk vs. non-risk patients, and evaluate the Screener and Opioid Assessment for Patients with Pain-Revised (SOAPP-R) against its shortened version (SOAPP-SF).
/patients. This cross-sectional study was conducted in a tertiary hospital's palliative care clinic. Adult patients with advanced cancer and cancer pain using or initiating prescribed opioids were included. Patients self-completed the SOAPP-R and SOAPP-SF during consultations. Additional data were gathered from medical records.
A total of 47 patients completed SOAPP-R and SOAPP-SF to assess NMOU risk, with 28% (n = 13) classified as high-risk by both. High-risk patients were younger (p = 0.003), received higher opioid doses (p = 0.026), used more substances (p = 0.018), and were more frequently employed (p = 0.001). SOAPP-SF showed 0.85 specificity, 0.6 sensitivity, 0.85 negative predictive value, and 0.6 positive predictive value compared to SOAPP-R. Both tests agreed on 61.5% of high-risk and 85% of low-risk cases.
Among outpatients with advanced cancer, 28% had high NMOU risk, which was associated with younger age, higher opioid doses, greater substance use, and higher employment rates. SOAPP-SF retained most of the predictive power of the SOAPP-R.
评估癌症门诊患者非医疗性阿片类药物使用（NMOU）风险频率，比较有风险与无风险患者，并对照其简化版（SOAPP-SF）评估疼痛患者筛查与阿片类药物评估修订版（SOAPP-R）。
/患者。本横断面研究在一家三级医院的姑息治疗诊所进行。纳入使用或开始使用处方阿片类药物的成年晚期癌症及癌症疼痛患者。患者在会诊期间自行完成SOAPP-R和SOAPP-SF。从病历中收集其他数据。
共有47名患者完成SOAPP-R和SOAPP-SF以评估NMOU风险，两者均将28%（n = 13）分类为高风险。高风险患者更年轻（p = 0.003），接受更高剂量阿片类药物（p = 0.026），使用更多物质（p = 0.018），且就业频率更高（p = 0.001）。与SOAPP-R相比，SOAPP-SF显示出0.85的特异性, 0.6的敏感性, 0.85的阴性预测值和0.6的阳性预测值。两种测试在61.5%的高风险病例和85%的低风险病例上达成一致。
在晚期癌症门诊患者中，28%有高NMOU风险，这与年龄较小、阿片类药物剂量较高、物质使用较多和就业率较高有关。SOAPP-SF保留了SOAPP-R的大部分预测能力。
