内分泌疾病对小儿唐氏综合征患者生长发育的患病率及影响：一项回顾性分析。
Prevalence and impact of endocrinopathies on growth in pediatric down syndrome patients: A retrospective analysis.
作者信息
Al Qassimi Ahmed M, Al Marzooq Rayan A, Alfaraj Lena H, Al Radhwan Nafisah M, Al-Askari Zainab A, AlKhalifah Ahmed S
机构信息
From the Pediatric Department, Qatif Central Hospital, Al Qatif, Kingdom of Saudi Arabia.
出版信息
Saudi Med J. 2025 Apr;46(4):364-371. doi: 10.15537/smj.2025.46.4.20241117.
OBJECTIVES
To assess the prevalence of endocrinopathies and their impact on growth among pediatric patients with Down syndrome (DS) in the Eastern Region of Saudi Arabia.
METHODS
This study utilized a retrospective cross-sectional design and was conducted at the Qatif Central Hospital between January 2015 and December 2022. Data from 358 pediatric patients with DS (aged 0-14 years), including clinical, anthropometric, and laboratory findings, were analyzed. The prevalence rates of endocrinopathies, their association with comorbidities, and their impact on growth metrics were evaluated using statistical methods.
RESULTS
Hypothyroidism was the most prevalent endocrinopathy (18.9%), followed by vitamin D deficiency (15.4%). Significant associations were observed between hypothyroidism and obesity (=0.009), as well as vitamin D deficiency (0.001). Growth impairment was common, with notable deviations in height and weight Z-scores among patients with hypothyroidism, vitamin D deficiency, and obstructive sleep apnea (<0.05).
CONCLUSION
Endocrinopathies are common among children with DS and substantially affect growth and health outcomes. Early screening and multidisciplinary management strategies are essential to improve patient care.
目的
评估沙特阿拉伯东部地区唐氏综合征（DS）儿科患者内分泌疾病的患病率及其对生长发育的影响。
方法
本研究采用回顾性横断面设计，于2015年1月至2022年12月在卡提夫中心医院进行。分析了358例DS儿科患者（年龄0 - 14岁）的数据，包括临床、人体测量和实验室检查结果。使用统计方法评估内分泌疾病的患病率、其与合并症的关联以及对生长指标的影响。
结果
甲状腺功能减退是最常见的内分泌疾病（18.9%），其次是维生素D缺乏（15.4%）。甲状腺功能减退与肥胖（P = 0.009）以及维生素D缺乏（P = 0.001）之间存在显著关联。生长发育障碍很常见，甲状腺功能减退、维生素D缺乏和阻塞性睡眠呼吸暂停患者的身高和体重Z评分有明显偏差（P < 0.05）。
结论
内分泌疾病在DS儿童中很常见，对生长发育和健康结果有重大影响。早期筛查和多学科管理策略对于改善患者护理至关重要。
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