Dagnaw Mequanente, Muche Achenef Asmamaw, Geremew Bisrat Misganaw, Gezie Lemma Derseh
Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.
Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia.
Front Public Health. 2025 Apr 4;13:1565621. doi: 10.3389/fpubh.2025.1565621. eCollection 2025.
Hepatitis B is a serious liver infection caused by the hepatitis B virus (HBV). Because of the shared modes of transmission, co-infections of HBV are common among people living with Human Immunodeficiency Virus (HIV) infection. While the use of antiretroviral therapy (ART) has significantly improved the life expectancy of HIV patients, hepatitis viral co-infections have become increasingly important. Particularly, HBV infection remains under-diagnosed and under-reported, despite its highly infectious nature. Therefore, this review was aimed at understanding the burden of hepatitis B disease among adults living with HIV receiving ART.
Using pertinent search terms, all research found in Google Scholar, HINARI, EMBAS, Scopus, and PubMed was located. Data were extracted following the evaluation of the evidence using the Joanna Briggs Institute's cross-sectional and cohort study methodologies.
A total of 18 groups involving 71,411 adults with HBV-HIV were selected for the study. Of those, 10.21% with 95% CI (5.06, 15.36) and 11.05% with 95% CI (2.78, 19.32) of HBV-HIV adults worldwide had an overall prevalence of HBV, with an I value of 0.0% (-value = 0.729) and an I value of 0.0% (-value = 0.818) from cross-sectional and cohort studies, respectively.
The global prevalence of people living with HBV-HIV is high, which poses a serious risk to public health. The review can clearly show the current pooled prevalence of HIV-HBV in the world, which may be helpful for policymakers because a large number of recent studies were included in it. Thus, it is strongly advised to broaden the current preventive and control program's purview and implement new, sensitive screening, testing, and treatment techniques. To raise community awareness, it would also be preferable to revamp the current prevention and control program and establish target-specific task forces at various health facility levels.
乙型肝炎是由乙型肝炎病毒（HBV）引起的一种严重肝脏感染。由于传播途径相同，HBV合并感染在人类免疫缺陷病毒（HIV）感染者中很常见。虽然抗逆转录病毒疗法（ART）的使用显著提高了HIV患者的预期寿命，但肝炎病毒合并感染变得越来越重要。特别是，尽管HBV感染具有高度传染性，但其诊断不足和报告不足的情况仍然存在。因此，本综述旨在了解接受ART治疗的HIV感染成人中乙型肝炎疾病的负担。
使用相关搜索词，在谷歌学术、HINARI、EMBASE、Scopus和PubMed中搜索到的所有研究均被找到。使用乔安娜·布里格斯研究所的横断面和队列研究方法对证据进行评估后提取数据。
共选择了18组涉及71411名HBV-HIV成人的研究。其中，全球HBV-HIV成人中HBV的总体患病率分别为10.21%，95%CI（5.06，15.36）和11.05%，95%CI（2.78，19.32），横断面研究和队列研究的I²值分别为0.0%（P值=0.729）和0.0%（P值=0.818）。
全球HBV-HIV感染者的患病率很高，这对公共卫生构成了严重风险。该综述可以清楚地显示当前全球HIV-HBV的合并患病率，这可能对政策制定者有所帮助，因为其中纳入了大量近期研究。因此，强烈建议扩大当前预防和控制计划的范围，实施新的、敏感的筛查、检测和治疗技术。为了提高社区意识，还最好修订当前的预防和控制计划，并在各级卫生机构建立针对特定目标的工作队。
