Liu Qiang, Huang He, Zhang Shuwen, Liu Fangteng, Lou Ting
Department of General Surgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, China.
Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Front Immunol. 2025 Apr 4;16:1480447. doi: 10.3389/fimmu.2025.1480447. eCollection 2025.
Long Intergenic Non-Protein Coding RNA 1123 (LINC01123), located on human chromosome 2q13, is a pivotal factor in tumorigenesis, exerting multifaceted oncogenic effects. Its expression strongly correlates with clinicopathological features, patient survival, and disease progression. and experiments further demonstrate that LINC01123 influences diverse cellular processes, including proliferation, apoptosis, viability, migration, invasion, stemness, and tumor growth. Notably, it also regulates metabolic reprogramming, immune escape, and tumor cell resistance to treatment. LINC01123 is regulated by multiple transcription factors and participates in gene regulation through protein interactions and competitive endogenous RNA (ceRNA) networks, thereby modulating cancer-promoting effects. This work systematically elucidates its primary functions and molecular mechanisms driving cancer initiation and progression, suggesting that LINC01123 might serve as a novel potential oncogenic driver and biomarker in various cancers.
长链基因间非编码RNA 1123（LINC01123）位于人类染色体2q13，是肿瘤发生中的关键因子，发挥多方面的致癌作用。其表达与临床病理特征、患者生存率及疾病进展密切相关。实验进一步证明，LINC01123影响多种细胞过程，包括增殖、凋亡、活力、迁移、侵袭、干性和肿瘤生长。值得注意的是，它还调节代谢重编程、免疫逃逸及肿瘤细胞的治疗抗性。LINC01123受多种转录因子调控，并通过蛋白质相互作用和竞争性内源性RNA（ceRNA）网络参与基因调控，从而调节促癌作用。这项工作系统地阐明了其驱动癌症发生和进展的主要功能及分子机制，表明LINC01123可能是多种癌症中一种新的潜在致癌驱动因子和生物标志物。
