Key Laboratory of TCM Prevention and Treatment of Chronic Diseases, School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Department of Medical Physics, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Cell Biochem Funct. 2024 Mar;42(2):e3961. doi: 10.1002/cbf.3961.
A substantial number of long noncoding RNAs (lncRNAs) have been identified as potent regulators of human disease. Human leukocyte antigen complex group 18 (HCG18) is a new type of lncRNA that has recently been proven to play an important role in the occurrence and development of various diseases. Studies have found that abnormal expression of HCG18 is closely related to the clinicopathological characteristics of many diseases. More importantly, HCG18 was also found to promote disease progression by affecting a series of cell biological processes. This article mainly discusses the expression characteristics, clinical characteristics, biological effects and related regulatory mechanisms of HCG18 in different human diseases, providing a scientific theoretical basis for its early clinical application.
大量长链非编码 RNA（lncRNA）已被鉴定为人类疾病的有效调节剂。人类白细胞抗原复合体 18 组（HCG18）是一种新型的 lncRNA，最近已被证明在各种疾病的发生和发展中发挥重要作用。研究发现，HCG18 的异常表达与许多疾病的临床病理特征密切相关。更重要的是，HCG18 还通过影响一系列细胞生物学过程来促进疾病的进展。本文主要讨论了 HCG18 在不同人类疾病中的表达特征、临床特征、生物学效应及其相关调控机制，为其早期临床应用提供了科学的理论基础。
