Chen Zhe, Ding Lina, Yu Jieni, Jin Jing, Zhang Zhijian, Fu Jiaping, Hong Pan, Fu Leihua
Department of Hematology, Shaoxing People's Hospital, Shaoxing, China.
Front Genet. 2025 Apr 4;16:1524177. doi: 10.3389/fgene.2025.1524177. eCollection 2025.
Our study aimed to investigate the effects of chromosomal aberrations and genetic mutations of elderly individuals diagnosed with AML and determine its prognostic significance.
We retrospectively collected data over nearly 7 years from our hospital, encompassing 90 cases of elderly AML patients. Baseline information of patients was gathered and followed up, and statistical analysis was conducted using SPSS 25.0.
Among the 90 elderly non-M3 AML patients, 56 (62.2%) exhibited multiple gene mutations, with 9 (10%) patients displaying five or more gene mutations. The incidence of mutation was significantly higher in patients with normal karyotypes compared to those with abnormal karyotypes (P = 0.001). Patients with , , or mutations displayed lower rates of CR compared to wild-type counterparts. Kaplan-Meier analysis revealed that mutation (P = 0.0474), mutation (P = 0.0364), mutation (P = 0.0031), and 17p abnormality (P = 0.00285) were predictive of shorter OS. mutations (P = 0.0440), 17p abnormalities (P = 0.0272), 7q abnormalities (P = 0.0174), and complex karyotypes (P = 0.0447) were associated with shorter RFS.
Our findings suggest that elderly AML patients exhibit distinctive genetic profiles, and favorable prognosis genes do not seem to apply to elderly AML patients.
我们的研究旨在调查老年急性髓系白血病（AML）患者的染色体畸变和基因突变情况，并确定其预后意义。
我们回顾性收集了我院近7年的数据，包括90例老年AML患者。收集患者的基线信息并进行随访，使用SPSS 25.0进行统计分析。
在90例老年非M3 AML患者中，56例（62.2%）表现出多种基因突变，其中9例（10%）患者有5种或更多基因突变。正常核型患者的突变发生率显著高于异常核型患者（P = 0.001）。与野生型相比，具有 、 或 突变的患者完全缓解（CR）率较低。Kaplan-Meier分析显示， 突变（P = 0.0474）、 突变（P = 0.0364）、 突变（P = 0.0031）和17p异常（P = 0.00285）预示总生存期（OS）较短。 突变（P = 0.0440）、17p异常（P = 0.0272）、7q异常（P = 0.0174）和复杂核型（P = 0.0447）与无复发生存期（RFS）较短相关。
我们的研究结果表明，老年AML患者表现出独特的基因特征，有利预后基因似乎不适用于老年AML患者。
