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阿司匹林和肝素术后用药监测控制方法的信息价值(作者译)

[Informative value of control methods for postoperative supervision of medication with aspirin and heparin (author's transl)].

作者信息

Schöndorf T H, Hey D

出版信息

MMW Munch Med Wochenschr. 1977 Jan 28;119(4):119-22.

PMID:402555
Abstract

Under the effect of acetylsalicyl lysin, a postoperative hypercoagulability was ascertained with regard to shortened antithrombin and partial prothrombin times. The inhibition of aggregation was easily demonstrable with a high concentration of collagen in the test batch and showed a striking relationship to the occurrence of thrombosis. Under heparin prophylaxis, normal coagulability was maintained. Since disorders of hemostasis due to therapy occur sporadically, early postoperative raising of the dose of heparin should only be done under regular laboratory controll, to which activated PTT and antithrombin time is well suited.

摘要

在乙酰水杨酸赖氨酸的作用下,观察到术后抗凝血酶和部分凝血活酶时间缩短,存在高凝状态。在测试批次中,高浓度胶原蛋白时聚集抑制作用易于证明,且与血栓形成的发生有显著关系。在肝素预防下,凝血功能维持正常。由于治疗引起的止血障碍偶尔发生,术后早期增加肝素剂量应仅在常规实验室监测下进行,活化部分凝血活酶时间和抗凝血酶时间对此很适用。

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