Rabinowitz L, Sarason R L, Yamauchi H
Am J Physiol. 1985 Aug;249(2 Pt 2):F263-71. doi: 10.1152/ajprenal.1985.249.2.F263.
To determine the quantitative relation of K excretion (UKV) to plasma K concentration (PK), three fasted, conscious, mature ewes were infused intravenously with 50 mmol KCl over 15, 30, and 60 min. Control experiments were without infusion. During KCl infusion PK was increased to 7.26 +/- 0.40 (15 min), 6.68 +/- 0.48 (30 min), and 5.59 +/- 0.3 meq/liter (60 min). During all three infusions the increase in UKV relative to the increase in PK was similar. The mean delta UKV/delta PK ratio was 160 +/- 30 (SD) mueq/min per meq/liter (range 102-203). On termination of each infusion PK decreased to control values, but UKV either remained elevated (60-min infusion) or first decreased and then increased (15- and 30-min infusions). The second, delayed kaliuresis began 30-45 min after initiation of KCl infusion and accelerated a return to the level of K balance of the control experiments. A plot of UKV against the corresponding period PK showed that, at a common value of PK, UKV was higher following KCl infusion when PK was dropping than during KCl infusion when PK was rising. The mechanisms responsible for this hysteresis phenomenon are not identified.
为了确定钾排泄量（UKV）与血浆钾浓度（PK）之间的定量关系，对三只禁食、清醒的成年母羊在15分钟、30分钟和60分钟内静脉输注50 mmol氯化钾。对照实验不进行输注。在输注氯化钾期间，PK分别升高至7.26±0.40（15分钟）、6.68±0.48（30分钟）和5.59±0.3 mEq/升（60分钟）。在所有三次输注过程中，UKV相对于PK的增加相似。UKV的平均变化量/ PK比值为160±30（标准差）μEq/分钟每mEq/升（范围为102 - 203）。每次输注结束时，PK降至对照值，但UKV要么保持升高（60分钟输注），要么先下降然后上升（15分钟和30分钟输注）。第二次延迟性尿钾增多在输注氯化钾开始后30 - 45分钟开始，并加速恢复到对照实验的钾平衡水平。将UKV与相应时间段的PK作图显示，在PK的共同值下，PK下降时氯化钾输注后的UKV高于PK上升时氯化钾输注期间的UKV。导致这种滞后现象的机制尚未明确。
