Zhou Jing, Zhao Ling, Liu Lianfang, He Li, Chen Yuanyuan, Wang Fang, Cui Dawei, Wang Lei, Zhou Qinfeng
Department of Laboratory Medicine, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, People's Republic of China.
Department of Oncology, Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Jiangsu, People's Republic of China.
J Inflamm Res. 2025 Apr 14;18:5061-5076. doi: 10.2147/JIR.S506644. eCollection 2025.
Non-small-cell lung cancer (NSCLC) is the predominant subtype of lung cancer. Despite the demonstrated effectiveness of established treatments such as radiotherapy, chemotherapy, and immunotherapy, the prognosis for patients with advanced NSCLC remains poor. Dendritic cells (DCs), the most potent antigen-presenting cells (APCs), play a crucial role in the tumor microenvironment (TME) of NSCLC. This review explores the classification and biological functions of DCs, highlighting the specific molecular pathways and external factors that influence their maturation and function in NSCLC, which is novel in this review. Moreover, we discuss the potential therapeutic applications of DCs in the management of NSCLC, presenting novel possibilities for future treatments.
非小细胞肺癌（NSCLC）是肺癌的主要亚型。尽管放疗、化疗和免疫疗法等既定治疗方法已显示出有效性，但晚期NSCLC患者的预后仍然很差。树突状细胞（DCs）是最有效的抗原呈递细胞（APCs），在NSCLC的肿瘤微环境（TME）中起关键作用。本综述探讨了DCs的分类和生物学功能，强调了影响其在NSCLC中成熟和功能的特定分子途径和外部因素，这在本综述中是新颖的。此外，我们讨论了DCs在NSCLC治疗中的潜在应用，为未来治疗提供了新的可能性。
