Liu Siqi, Yang Ailin, Yu Yue, Xu Bo, Yu Ganggang, Wang Haoyan
Department of Respiratory Medicine, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Department of Respiratory and Critical Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2025 Apr 15;20:1071-1082. doi: 10.2147/COPD.S512275. eCollection 2025.
Exercise rehabilitation training has emerged as one of the most promising modalities for enhancing clinical outcomes and overall well-being in patients with chronic obstructive pulmonary disease (COPD). Distinct exercise prescriptions yield different clinical benefits in this population. Endurance training has been demonstrated to significantly improve exercise capacity, alleviate dyspnea, and enhance health-related quality of life metrics. High-intensity interval training offers a time-efficient approach to boosting cardiorespiratory fitness and metabolic function. Resistance training addresses progressive muscle atrophy through targeted myofiber recruitment, thereby augmenting musculoskeletal performance and translating to enhanced exercise tolerance in patients with COPD. Exercise-mediated rehabilitation attenuates COPD progression and mitigates acute exacerbation risks via multifactorial mechanisms such as mitigation of inflammatory responses, reduction of oxidative stress, and improvement of endothelial cell function. Elucidating the pathophysiological mechanisms underlying exercise-induced benefits will pave the way for precision rehabilitation protocols, ultimately advancing COPD disease management paradigms, refining patient-centered outcome measures, and achieving sustainable health optimization in this clinical cohort.
运动康复训练已成为改善慢性阻塞性肺疾病（COPD）患者临床结局和整体健康状况最有前景的方法之一。不同的运动处方对这一人群有不同的临床益处。耐力训练已被证明能显著提高运动能力、缓解呼吸困难，并改善与健康相关的生活质量指标。高强度间歇训练提供了一种提高心肺适能和代谢功能的高效方法。阻力训练通过有针对性地募集肌纤维来解决进行性肌肉萎缩问题，从而增强肌肉骨骼性能，并转化为COPD患者运动耐力的提高。运动介导的康复通过多种机制减缓COPD进展并降低急性加重风险，如减轻炎症反应、减少氧化应激和改善内皮细胞功能。阐明运动诱导益处背后的病理生理机制将为精准康复方案铺平道路，最终推动COPD疾病管理模式的发展，完善以患者为中心的结局指标，并在这一临床队列中实现可持续的健康优化。
