Zhang Chenjiao, Ma Jinbao, Gao Huanqin, Luo Yanhong, Feng Junhui, Wei Yanyan, Chen Jingxu
School of Mental Health, Bengbu Medical University, Bengbu, Anhui, China.
Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China.
Front Psychiatry. 2025 Apr 4;16:1525091. doi: 10.3389/fpsyt.2025.1525091. eCollection 2025.
It is thought that inflammation significantly contributes to the development of bipolar disorder (BD), and recent findings indicate a connection between cystatin C and immune-related inflammation. In this study, we investigated serum cystatin C levels in patients with BD and explored the relationship between cystatin C and inflammatory markers.
The study involved 3,647 individuals diagnosed with BD, comprising 2,431 with BD-manic (BD-M) and 1,216 with BD-depression (BD-D), alongside 3,500 healthy controls. The analysis covered cystatin C levels and inflammatory biomarkers obtained from complete blood counts across the various groups. The Spearman correlation test was used to examine the relationship between cystatin C and inflammatory markers. Logistic regression and ROC curve analyses assessed the predictive value of these markers for disease occurrence.
Serum cystatin C levels were significantly elevated in BD patients, particularly those in manic episodes, compared to the healthy control group, with distinct correlation patterns with inflammatory biomarkers observed among the groups. Serum Cystatin C levels independently and positively indicated disease occurrence, showing improved diagnostic effectiveness when combined with inflammatory ratios.
Our research indicates that cystatin C could be involved in the pathophysiological mechanisms of BD by affecting pro-inflammatory processes. Additionally, it should be emphasized that cystatin C showed considerable predictive capacity in diagnosing BD, especially when used alongside various inflammatory markers.
The cross-sectional study is limited to demonstrating associations rather than establishing causality. A thorough examination of sociodemographic factors and the severity of the disease could not be conducted.
人们认为炎症在双相情感障碍（BD）的发展中起重要作用，最近的研究结果表明胱抑素C与免疫相关炎症之间存在联系。在本研究中，我们调查了BD患者的血清胱抑素C水平，并探讨了胱抑素C与炎症标志物之间的关系。
该研究纳入了3647名被诊断为BD的个体，其中2431名为躁狂发作的BD患者（BD-M），1216名为抑郁发作的BD患者（BD-D），以及3500名健康对照者。分析涵盖了各组全血细胞计数中获得的胱抑素C水平和炎症生物标志物。采用Spearman相关性检验来检查胱抑素C与炎症标志物之间的关系。逻辑回归和ROC曲线分析评估了这些标志物对疾病发生的预测价值。
与健康对照组相比，BD患者的血清胱抑素C水平显著升高，尤其是处于躁狂发作期的患者，且各组间观察到与炎症生物标志物有明显的相关性模式。血清胱抑素C水平独立且正向地提示疾病发生，与炎症比值联合使用时显示出更高的诊断效能。
我们的研究表明，胱抑素C可能通过影响促炎过程参与BD的病理生理机制。此外，应强调的是，胱抑素C在诊断BD方面显示出相当大的预测能力，特别是与各种炎症标志物一起使用时。
横断面研究仅限于证明关联而非确定因果关系。无法对社会人口统计学因素和疾病严重程度进行全面检查
