含多元酸复合物和烟酰胺的皮肤美容血清对日本轻度痤疮女性的疗效评估。
Evaluation of a Dermocosmetic Serum Containing a Multi-acid Complex and Niacinamide in Japanese Women with Mild Acne.
作者信息
Igarashi Atsuyuki, Abe Masatoshi, Gunji Yurie, Nemoto Osamu, Kawamura Kuniko, Yokozeki Mayumi, Saito Atsushi, Ookawara Akira
机构信息
Dr. Igarashi is with Igarashi Dermatology Clinic Higashi Gotanda in Tokyo, Japan.
Drs. Abe, Nemoto, Kawamura, Yokozeki, Saito, and Ookawara are with Medical Corporation Kojinkai, in Sapporo, Japan.
出版信息
J Clin Aesthet Dermatol. 2025 Apr;18(4):41-43.
BACKGROUND
Acne is a common inflammatory dermatosis in all parts of the world, including Japan. While effective prescription treatments are available, patients often prefer to try to manage their acne, particularly when it is mild, using over-the-counter (OTC) approaches.
OBJECTIVE
This open-label study evaluated the efficacy and safety of an OTC serum containing a multi-acid complex and niacinamide (niacinamide 2%, lactic acid 1%, hydroxyethylpiperazine ethane sulfuric acid [HEPES] 0.5%, phytic acid 0.2%, and salicylic acid 0.2%) used twice daily for eight weeks in Japanese women aged 16 to 34 years with acne.
METHODS
An eight-week, split-face, open-label study of multi-acid complex and niacinamide containing dermocosmetic used twice daily in Japanese women aged 16 to 34 years was conducted. Participants had mild-to-moderate inflammatory acne (up to 20 inflammatory lesions on half the face) and assessments included number and severity of acne lesions as well as standard safety assessments.
RESULTS
A total of 50 women enrolled, with 46 eligible for evaluation at Week 8. Significant improvements in acne severity, the number of inflammatory lesions, and skin texture as indicated by pore size were observed (<0.05 for all). In addition, patients' quality of life significantly improved from baseline to Week 8 (<0.01). The serum was well tolerated. Four cases of skin discomfort were reported; all were mild in severity and resolved spontaneously.
CONCLUSION
This multi-acid/niacinamide OTC serum effectively improved acne in Japanese women.
背景
痤疮是一种在包括日本在内的世界各地都很常见的炎症性皮肤病。虽然有有效的处方治疗方法，但患者通常更愿意尝试自行管理痤疮，尤其是在痤疮较轻时，采用非处方（OTC）方法。
目的
这项开放标签研究评估了一种含有多种酸复合物和烟酰胺（烟酰胺2%、乳酸1%、羟乙基哌嗪乙烷磺酸[HEPES]0.5%、植酸0.2%和水杨酸0.2%）的非处方精华液，在16至34岁患有痤疮的日本女性中每日使用两次，持续八周的疗效和安全性。
方法
对16至34岁的日本女性进行了一项为期八周的、半脸、开放标签的研究，该研究使用了含有多种酸复合物和烟酰胺的皮肤美容产品，每日使用两次。参与者患有轻度至中度炎症性痤疮（半脸最多20个炎症性皮损），评估包括痤疮皮损的数量和严重程度以及标准安全性评估。
结果
共有50名女性入组，46名在第8周符合评估条件。观察到痤疮严重程度、炎症性皮损数量以及毛孔大小所表明的皮肤质地有显著改善（所有P<0.05）。此外，患者的生活质量从基线到第8周有显著改善（P<0.01）。该精华液耐受性良好。报告了4例皮肤不适；所有症状均为轻度，且自行缓解。
结论
这种多种酸/烟酰胺非处方精华液有效改善了日本女性的痤疮。
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