Towersey Loan, Correia Priscila, Fajgenbaum Feiges Mariana, Euzébio Gonçalves Junior José, Sant'Anna Beatriz, Kerob Delphine, Le Floc'h Caroline
Dermatology Department, Carlos Tortely Hospital, Niterói, Rio de Janeiro, Brazil.
Scientific Expertise, L'Oreal Brazil, Rio de Janeiro, Rio de Janeiro, Brazil.
Clin Cosmet Investig Dermatol. 2023 Jan 18;16:119-123. doi: 10.2147/CCID.S394123. eCollection 2023.
Acne is a skin condition of the pilosebaceous unit that affects mainly the face, chest and trunk. Approximately 50% of subjects with facial acne also have acne of the trunk. This study investigated the clinical benefit of a cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% in truncal acne after 84 days of daily use.
A single center, open label, non-randomized study with 51 subjects with mild to moderate truncal acne was conducted. Thirty-five (35) subjects completed the study; mean age was 23 years. Inflammatory and non-inflammatory lesions, Transepidermal water loss (TEWL) and local tolerance were assessed at baseline, Day 42 and Day 84 and total lesion count was calculated.
The total lesion count was significantly reduced (p<0.05) after 42 days (-21.5%) and 84 days (-56.3%). Non-inflammatory lesions were significantly decreased after 84 days (-64.0%) only, while inflammatory lesions were decreased at Day 42 (-29.2%), and Day 84 (-48.2%). A statistically significant skin barrier improvement was observed at Day 84 (-21.26%). No adverse events or relevant local intolerance were reported.
The use of the cleansing gel studied was effective in improving mild to moderate truncal acne and contributed to the skin barrier improvement. The product was well tolerated.
NCT05584150.
痤疮是一种累及毛囊皮脂腺单位的皮肤疾病，主要影响面部、胸部和躯干。约50%的面部痤疮患者也有躯干痤疮。本研究调查了每日使用含2%水杨酸、0.2%葡萄糖酸锌和0.05%脂羟基酸的洁面凝胶84天后，对躯干痤疮的临床疗效。
进行了一项单中心、开放标签、非随机研究，纳入51例轻至中度躯干痤疮患者。35名受试者完成了研究；平均年龄为23岁。在基线、第42天和第84天评估炎症性和非炎症性皮损、经表皮水分流失（TEWL）和局部耐受性，并计算皮损总数。
42天（-21.5%）和84天（-56.3%）后，皮损总数显著减少（p<0.05）。仅在84天后非炎症性皮损显著减少（-64.0%），而炎症性皮损在第42天（-29.2%）和第84天（-48.2%）减少。在第84天观察到皮肤屏障有统计学意义的改善（-21.26%）。未报告不良事件或相关局部不耐受情况。
所研究的洁面凝胶可有效改善轻至中度躯干痤疮，并有助于改善皮肤屏障。该产品耐受性良好。
NCT05584150。
