在地方性流行社区中，通过皮肤试验反应性对粗球孢子菌感染的估计。
Estimates of C. immitis infection by skin test reactivity in an endemic community.
作者信息
Dodge R R, Lebowitz M D, Barbee R, Burrows B
出版信息
Am J Public Health. 1985 Aug;75(8):863-5. doi: 10.2105/ajph.75.8.863.
Abstract
This report is a comparison of two delayed hypersensitivity skin test reagents, coccidioidin and Spherulin, available for detection of prior infection by Coccidioides immitis. Coccidioidin proved to be a somewhat more sensitive reagent (33.4 per cent positive, vs 29.6 per cent for Spherulin). This difference persisted in the subjects when grouped by age, sex, exposure history, or history of coccidioidomycosis. Skin test reactivity to both reagents declined with age. Independent of exposure history coccidioidin detected 7.3 per cent of the subjects who were not detected by Spherulin; Spherulin detected prior infection in only 3.5 per cent of the subjects not detected by coccidioidin. These results differ from those of previously reported studies.
摘要
本报告比较了两种用于检测既往球孢子菌感染的迟发型超敏皮肤试验试剂，即球孢子菌素和球孢子菌抗原。结果表明，球孢子菌素是一种更为敏感的试剂（阳性率为33.4%，而球孢子菌抗原为29.6%）。按年龄、性别、接触史或球孢子菌病病史分组时，这种差异在受试者中持续存在。两种试剂的皮肤试验反应性均随年龄下降。与接触史无关，球孢子菌素检测出了7.3%未被球孢子菌抗原检测出的受试者；球孢子菌抗原仅在3.5%未被球孢子菌素检测出的受试者中检测到既往感染。这些结果与先前报道的研究结果不同。
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