Saravia N G, Holguín A F, McMahon-Pratt D, D'Alessandro A
Am J Trop Med Hyg. 1985 Jul;34(4):714-20. doi: 10.4269/ajtmh.1985.34.714.
It is generally held that with rare exception Leishmania braziliensis braziliensis is the parasite responsible for the metastatic development of mucocutaneous leishmaniasis in the New World. Yet the infrequency of mucocutaneous disease compared with cutaneous manifestations, and the difficulty of isolating parasites from mucocutaneous lesions have restricted the study of the organisms involved. We here report the biologic, isoenzymatic, and monoclonal antibody specificity characteristic of eight Leishmania isolates obtained from the mucosal lesions of the same number of patients. Individually and collectively, the identifying criteria implicate at least two L. braziliensis subspecies as etiologic agents of mucocutaneous leishmaniasis in Colombia and suggest that a spectrum of intrinsically distinguishable organisms may be involved in this disease form.
一般认为，除极少数例外情况外，巴西利什曼原虫巴西亚种是新大陆黏膜皮肤利什曼病转移发展的病原体。然而，与皮肤表现相比，黏膜皮肤疾病的发生率较低，且从黏膜皮肤病变中分离寄生虫存在困难，这限制了对相关生物体的研究。我们在此报告从相同数量患者的黏膜病变中获得的8株利什曼原虫分离株的生物学、同工酶和单克隆抗体特异性特征。单独或综合来看，这些鉴定标准表明至少有两个巴西利什曼原虫亚种是哥伦比亚黏膜皮肤利什曼病的病原体，并提示一系列本质上可区分的生物体可能与这种疾病形式有关。
