缺血性脑卒中中骨髓间充质干细胞研究的文献计量分析与可视化研究

Bibliometric Analysis and Visualized Study of Research on Mesenchymal Stem Cells in Ischemic Stroke.

作者信息

Bu Fanwei, Yuan Xinmei, Cui Xiaocan, Guo Ruyue

机构信息

Xinxiang First People's Hospital, Xinxiang, China.

Huaxian People's Hospital, Anyang, China.

出版信息

Stem Cell Rev Rep. 2025 Apr 21. doi: 10.1007/s12015-025-10878-9.

DOI:10.1007/s12015-025-10878-9

PMID:40257541

Abstract

BACKGROUND

One of the major global causes of death and disability is ischemic stroke (IS). Mesenchymal stem cells (MSCs) emerge as a cell-based therapy for numerous diseases. Recently, research on the role of MSCs in ischemic stroke has developed rapidly worldwide. Bibliometric analysis of MSCs for IS has not yet been published, though.

AIM

Through bibliometric analysis, the aim of this study was to assess the current state of research on MSCs in the field of ischemic stroke research worldwide and to identify important results, major research areas, and emerging trends.

METHODS

Publications related to MSCs in ischemic stroke from January 1, 2002, to December 31, 2022, were obtained from the Web of Science Core Collection (WoSCC). We used HistCite, VOSViewer, CiteSpace, and Bibliometrix for bibliometric analysis and visualization. We employed the Total Global Citation Score (TGCS) to assess the impact of publications.

RESULTS

The bibliometric analysis included a total of 2,048 publications. The 1,386 papers used in this study were authored by 200 individuals across 200 organizations in 72 countries, published in 202 journals. Cesar V Borlongan published the most documents among high-productivity authors. Michael Chopp was the author with the highest average number of citations per paper, with an average paper citation time of 118.54. We found that research of MSCs in ischemic stroke developed rapidly starting in 2008. Neurosciences were the most productive journals, and Chinese researchers have produced the most research papers in this subject. The most cited article is "Systemic administration of exosomes released from mesenchymal stromal cells promotes functional recovery and neurovascular plasticity after stroke in rats".

CONCLUSION

This study uses both numbers and descriptions to thoroughly review the research on MSCs related to IS. This information provides valuable experience for researchers to carry out MSCs' work on IS.

摘要

背景

缺血性中风（IS）是全球主要的死亡和残疾原因之一。间充质干细胞（MSCs）作为一种基于细胞的疗法，可用于治疗多种疾病。近年来，全球范围内关于MSCs在缺血性中风中作用的研究发展迅速。不过，尚未有关于MSCs治疗缺血性中风的文献计量学分析发表。

目的

通过文献计量学分析，本研究旨在评估全球缺血性中风研究领域中MSCs的研究现状，识别重要成果、主要研究领域和新趋势。

方法

从Web of Science核心合集（WoSCC）获取2002年1月1日至2022年12月31日期间与缺血性中风中MSCs相关的出版物。我们使用HistCite、VOSViewer、CiteSpace和Bibliometrix进行文献计量分析和可视化。我们采用全球总被引分数（TGCS）来评估出版物的影响力。

结果

文献计量分析共纳入2048篇出版物。本研究使用的1386篇论文由来自72个国家200个组织的200位作者撰写，发表在202种期刊上。在高产作者中，塞萨尔·V·博隆甘发表的文献最多。迈克尔·乔普是每篇论文平均被引次数最高的作者，平均每篇论文被引118.54次。我们发现，2008年起，缺血性中风中MSCs的研究迅速发展。神经科学领域的期刊发文量最多，中国研究人员在该主题上发表的研究论文最多。被引次数最多的文章是《间充质基质细胞释放的外泌体全身给药促进大鼠中风后功能恢复和神经血管可塑性》。