Chahar Omvir Singh, Raina Sheetal, Rizwan Ahmad, Nayyar Supreet Singh, Tripathi Shailendra, Bhatnagar Akshay, Singh Ombir, Bisht Nandini, Dixit Mohneesh
Department of Otorhinolaryngology & Head Neck Surgery, Command Hospital Central Command, Lucknow, Uttar Pradesh, 226002, India.
Eur Arch Otorhinolaryngol. 2025 Jun;282(6):3097-3101. doi: 10.1007/s00405-025-09392-y. Epub 2025 Apr 21.
To study the efficacy of nasal saline irrigation combined with intranasal corticosteroids in treating Allergic Rhinitis and compare it with intranasal corticosteroids alone.
A prospective, randomized trial conducted at a tertiary care center. Symptomatic individuals diagnosed with Allergic Rhinitis were included. The control group received fluticasone propionate nasal spray (200 mcg/day) and the treatment group received fluticasone propionate nasal spray (200 mcg/day) along with nasal saline irrigation with isotonic normal saline (50 ml/nostril with each irrigation thrice a day). The two groups were followed up for 12 weeks. The outcome was compared using a patient-reported experience measure "Allergic rhinitis scoring system".
A total of 120 patients (60 in each group) were included in the study. Pre-intervention, there were no significant differences between the two groups with the Allergic rhinitis scoring system. Post-Intervention, significant improvements were evident across all assessed symptoms: rhinorrhoea (14.93 ± 4.16 vs. 17.80 ± 3.16, p < 0.0001), sneezing (14.40 ± 3.91 vs. 18.27 ± 3.16, p < 0.0001), nasal blockage (10.47 ± 4.66 vs. 13.80 ± 4.80, p = 0.0002), nasal pruritus (17.93 ± 3.17 vs. 19.13 ± 1.96, p = 0.0140), ocular pruritus (18.60 ± 2.84 vs. 19.13 ± 2.22, p = 0.2537), and total Allergic rhinitis scoring system score (77.00 ± 9.79 vs. 88.13 ± 7.70, p < 0.0001).
Nasal saline irrigation used in conjunction with intranasal corticosteroids more effectively alleviates all symptoms of Allergic rhinitis. However, there was no significant difference in ocular pruritus in both groups.
Trial registered with Clinical trial registry-India, CTRI/2023/01/048641. URL: https://ctri.nic.in/Clinicaltrials/main1.php?EncHid=44058.73881 .
研究鼻腔盐水冲洗联合鼻用糖皮质激素治疗变应性鼻炎的疗效，并与单纯使用鼻用糖皮质激素进行比较。
在一家三级医疗中心进行的一项前瞻性随机试验。纳入被诊断为变应性鼻炎的有症状个体。对照组接受丙酸氟替卡松鼻喷雾剂（200微克/天），治疗组接受丙酸氟替卡松鼻喷雾剂（200微克/天）以及用等渗生理盐水进行鼻腔冲洗（每侧鼻孔50毫升，每天冲洗三次）。两组随访12周。使用患者报告的经验性测量指标“变应性鼻炎评分系统”比较结果。
该研究共纳入120例患者（每组60例）。干预前，两组在变应性鼻炎评分系统方面无显著差异。干预后，所有评估症状均有显著改善：流涕（14.93±4.16对17.80±3.16，p<0.0001）、打喷嚏（14.40±3.91对18.27±3.16，p<0.0001）、鼻塞（10.47±4.66对13.80±4.80，p = 0.0002）、鼻痒（17.93±3.17对19.13±1.96，p = 0.0140）、眼痒（18.60±2.84对19.13±2.22，p = 0.2537）以及变应性鼻炎评分系统总分（77.00±9.79对88.13±7.70，p<0.0001）。
鼻腔盐水冲洗联合鼻用糖皮质激素能更有效地缓解变应性鼻炎的所有症状。然而，两组在眼痒方面无显著差异。
该试验已在印度临床试验注册中心注册，CTRI/2023/01/048641。网址：https://ctri.nic.in/Clinicaltrials/main1.php?EncHid=44058.73881 。
