Cont Celine, Reinboth Barbara S, Schütz Carolin, Stute Nathalie, Galli Anastasia, Schulte Christina, Wojtecki Lars
Department of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Duesseldorf; Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf; Neurologische Praxis am Neurozentrum Kempen, Prof. Dr. med. Lars Wojtecki.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich-Heine-University Düsseldorf.
J Vis Exp. 2025 Apr 4(218). doi: 10.3791/67176.
Transcranial pulse stimulation (TPS) is a noninvasive neuromodulation therapy with Conformité Européenne (CE) marking for the treatment of Alzheimer's disease (AD). Initial pilot studies have demonstrated promising effects on cognitive function. This article focuses on the procedure for treating patients with AD using an MRI-guided, neuro-navigated TPS device. The protocol to be followed for this is described in detail, including the necessary procedures and device settings. A brief overview of the representative clinical results published to date is also provided. In addition to significant clinical improvements in cognition and affect, adverse events (AE) and possible adverse device events (ADE) are presented to provide safety data. Finally, the method is critically discussed. In the future, randomized controlled trials should be conducted to rule out any placebo effects. There is also currently a lack of long-term studies with a larger number of patients. Despite these unresolved questions, TPS has the potential as an adjunct treatment for Alzheimer's patients when used in a controlled, scientifically guided setting.
经颅脉冲刺激（TPS）是一种具有欧洲合格认证（CE）标志的非侵入性神经调节疗法，用于治疗阿尔茨海默病（AD）。初步的试点研究已证明其对认知功能有显著效果。本文重点介绍使用磁共振成像（MRI）引导、神经导航TPS设备治疗AD患者的操作过程。详细描述了为此应遵循的方案，包括必要的程序和设备设置。还简要概述了迄今为止发表的代表性临床结果。除了认知和情感方面的显著临床改善外，还介绍了不良事件（AE）和可能的不良设备事件（ADE）以提供安全性数据。最后，对该方法进行了批判性讨论。未来，应进行随机对照试验以排除任何安慰剂效应。目前也缺乏对大量患者的长期研究。尽管存在这些未解决的问题，但在可控的、科学指导的环境中使用时，TPS有潜力作为阿尔茨海默病患者的辅助治疗方法。
