Javaheri Zahra, Jafari-Pozve Sogol, Jafari-Pozve Nasim, Aryanezhad Seyed Sasan, Arianezhad S Marjan
Gen Dent. 2025 May-Jun;73(3):35-41.
Pulp stones result from the calcification of dental pulp tissue. There is limited research on pulp stones in unerupted teeth, but they are more suitable for investigating the influence of systemic factors on pulp stone formation because they are not exposed to the conditions of the oral cavity. The objectives of this cross-sectional descriptive-analytical study were to use cone beam computed tomography (CBCT) to evaluate pulp stones in unerupted teeth and to be the first investigation to assess the correlation between pulp stones and blood levels of principal biochemical factors. The CBCT records of 90 patients were evaluated, and 3 groups were defined based on the size of pulp stones: small pulp stone (including total absence as well as minute particles with maximum diameter < 0.05 mm); moderate-sized pulp stone (maximum diameter 0.05-1.59 mm); or large pulp stone (maximum diameter ≥ 1.60 mm). This was followed by assessment of the patients' blood levels of 5 principal biochemical factors: fasting blood glucose (FBG), total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL). The data were analyzed by chi-square test, 1-way analysis of variance, and Kruskal-Wallis test, and values of P < 0.05 were considered statistically significant. Individuals with a large pulp stone were significantly older than individuals with a small pulp stone (P = 0.024). No statistically significant difference was found in the distribution of the sexes in the 3 pulp stone groups, nor was there any association between pulp stones in unerupted teeth and FBG, total cholesterol, triglycerides, HDL, or LDL level (P > 0.05). The prevalence of tooth types followed a consistent pattern across all 3 groups, with canines being the most commonly affected, followed by premolars. In the present study, confounding variables were minimized by using unerupted teeth. CBCT was found to be an accurate 3-dimensional imaging modality for evaluation of pulp stones. As people age, the likelihood of pulp stone formation increases. No statistically significant association was observed between the prevalence of pulp stones and patients' sex or biochemical factor levels.
牙髓石是由牙髓组织钙化形成的。关于未萌出牙齿中牙髓石的研究有限，但由于它们未暴露于口腔环境中，因此更适合用于研究全身因素对牙髓石形成的影响。这项横断面描述性分析研究的目的是使用锥形束计算机断层扫描（CBCT）评估未萌出牙齿中的牙髓石，并首次评估牙髓石与主要生化因子血液水平之间的相关性。对90例患者的CBCT记录进行了评估，并根据牙髓石的大小定义了3组：小牙髓石（包括完全没有以及最大直径<0.05mm的微小颗粒）；中等大小的牙髓石（最大直径0.05 - 1.59mm）；或大牙髓石（最大直径≥1.60mm）。随后评估了患者血液中5种主要生化因子的水平：空腹血糖（FBG）、总胆固醇、甘油三酯、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）。数据采用卡方检验、单因素方差分析和Kruskal - Wallis检验进行分析，P<0.05的值被认为具有统计学意义。有大牙髓石的个体明显比有小牙髓石的个体年龄大（P = 0.024）。在3个牙髓石组中，性别分布没有统计学上的显著差异，未萌出牙齿中的牙髓石与FBG、总胆固醇、甘油三酯、HDL或LDL水平之间也没有任何关联（P>0.05）。在所有3组中，牙齿类型的患病率遵循一致的模式，犬齿受影响最常见，其次是前磨牙。在本研究中，通过使用未萌出牙齿将混杂变量降至最低。发现CBCT是评估牙髓石的一种准确的三维成像方式。随着年龄增长，牙髓石形成的可能性增加。未观察到牙髓石患病率与患者性别或生化因子水平之间存在统计学上的显著关联。
