Ma Xinxin, Liu Yueying, Xie Miaoxian, Li Chunmei, Li Xinyang, Shang Dandan, Chen Min, Chen Haibo, Su Wen
Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
NPJ Parkinsons Dis. 2025 Apr 21;11(1):82. doi: 10.1038/s41531-025-00962-9.
This study aimed to evaluate the glymphatic system activity in Parkinson's disease (PD) with and without rapid eye movement sleep behavior disorder (RBD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods. Overall, 91 patients with PD and 33 healthy controls were recruited. PD patients were divided into PD-RBD (n = 55) and PD-nRBD (n = 36) groups according to RBD scales. The ALPS-index and enlarged perivascular spaces (EPVS) scores were calculated. PD-RBD group exhibited lower ALPS-index than PD-nRBD and controls after controlling for the effect of age (p = 0.018 and p = 0.001). PD-RBD group showed higher UPDRS part I and HAMD score than those in PD-nRBD group. RBD symptom was independently correlated with ALPS-index in PD (β = -0.259, p = 0.014). In conclusion, PD with possible RBD correlated with more severe glymphatic system dysfunction and non-motor symptoms than those in PD without RBD.
本研究旨在采用沿血管周围间隙的扩散张量成像分析（DTI-ALPS）方法，评估伴有和不伴有快速眼动睡眠行为障碍（RBD）的帕金森病（PD）患者的类淋巴系统活性。总共招募了91例PD患者和33名健康对照者。根据RBD量表，将PD患者分为PD-RBD组（n = 55）和PD-nRBD组（n = 36）。计算ALPS指数和扩大的血管周围间隙（EPVS）评分。在控制年龄影响后，PD-RBD组的ALPS指数低于PD-nRBD组和对照组（p = 0.018和p = 0.001）。PD-RBD组的UPDRS第一部分和HAMD评分高于PD-nRBD组。RBD症状与PD患者的ALPS指数独立相关（β = -0.259，p = 0.014）。总之，与无RBD的PD患者相比，可能伴有RBD的PD患者的类淋巴系统功能障碍和非运动症状更严重。
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