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Linking bacterial androgen production and prostate cancer.

作者信息

Arp Gabriela, Levy Sophia, Hall Brantley

机构信息

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, College Park, MD, USA.

Center for Bioinformatics and Computational Biology, University of Maryland, College Park, College Park, MD, USA.

出版信息

Nat Microbiol. 2025 May;10(5):1038-1039. doi: 10.1038/s41564-025-01996-8.

DOI:10.1038/s41564-025-01996-8
PMID:40259018
Abstract
摘要

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The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer.脂肪细胞分泌的激素瘦素对雄激素抵抗的前列腺癌细胞有增殖作用，将肥胖与前列腺癌的晚期阶段联系起来。
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TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer.通过易位或间质性缺失形成的TMPRSS2:ERG融合在雄激素依赖性前列腺癌中高度相关，但在晚期雄激素受体阴性前列腺癌中则不存在。
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Regions of prostate-specific antigen (PSA) promoter confer androgen-independent expression of PSA in prostate cancer cells.前列腺特异性抗原（PSA）启动子区域可使前列腺癌细胞中PSA呈现雄激素非依赖性表达。
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本文引用的文献

1
An expanded metabolic pathway for androgen production by commensal bacteria.共生细菌产生雄激素的扩展代谢途径。
Nat Microbiol. 2025 May;10(5):1084-1098. doi: 10.1038/s41564-025-01979-9. Epub 2025 Apr 21.
2
Profiling Salmonella transcriptional dynamics during macrophage infection using a comprehensive reporter library.利用全面的报告基因文库分析巨噬细胞感染期间沙门氏菌的转录动力学。
Nat Microbiol. 2025 Apr;10(4):1006-1023. doi: 10.1038/s41564-025-01953-5. Epub 2025 Apr 2.
3
A biosynthetic pathway for the selective sulfonation of steroidal metabolites by human gut bacteria.
人肠道细菌中甾体代谢物选择性磺化的生物合成途径。
Nat Microbiol. 2022 Sep;7(9):1404-1418. doi: 10.1038/s41564-022-01176-y. Epub 2022 Aug 18.
4
Androstenedione (a Natural Steroid and a Drug Supplement): A Comprehensive Review of Its Consumption, Metabolism, Health Effects, and Toxicity with Sex Differences.雄烯二酮（一种天然类固醇和药物补充剂）：其消费、代谢、健康影响和毒性的全面综述，以及性别差异。
Molecules. 2021 Oct 14;26(20):6210. doi: 10.3390/molecules26206210.
5
A metabolic pathway for bile acid dehydroxylation by the gut microbiome.肠道微生物组胆汁酸去羟化的代谢途径。
Nature. 2020 Jun;582(7813):566-570. doi: 10.1038/s41586-020-2396-4. Epub 2020 Jun 17.
6
Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level.未培养的人体肠道细菌对胆固醇代谢的影响宿主胆固醇水平。
Cell Host Microbe. 2020 Aug 12;28(2):245-257.e6. doi: 10.1016/j.chom.2020.05.013. Epub 2020 Jun 15.
7
Bacterial steroid-17,20-desmolase is a taxonomically rare enzymatic pathway that converts prednisone to 1,4-androstanediene-3,11,17-trione, a metabolite that causes proliferation of prostate cancer cells.细菌甾体 17,20-脱羟酶是一种分类上罕见的酶途径，可将泼尼松龙转化为 1,4-雄烷二烯-3,11,17-三酮，这是一种导致前列腺癌细胞增殖的代谢物。
J Steroid Biochem Mol Biol. 2020 May;199:105567. doi: 10.1016/j.jsbmb.2019.105567. Epub 2019 Dec 20.
8
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.肠道微生物组对癌症、免疫和癌症免疫治疗的影响。
Cancer Cell. 2018 Apr 9;33(4):570-580. doi: 10.1016/j.ccell.2018.03.015.
9
The and genes from ATCC 35704 encode steroid-17,20-desmolase.该菌 ATCC 35704 的 和 基因编码甾体 17,20-裂合酶。
J Lipid Res. 2018 Jun;59(6):1005-1014. doi: 10.1194/jlr.M083949. Epub 2018 Mar 23.
10
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens.凝结梭菌：一种具有将糖皮质激素转化为雄激素的高潜力的人类肠道微生物。
J Lipid Res. 2013 Sep;54(9):2437-49. doi: 10.1194/jlr.M038869. Epub 2013 Jun 15.