肠道微生物组对癌症、免疫和癌症免疫治疗的影响。
The Influence of the Gut Microbiome on Cancer, Immunity, and Cancer Immunotherapy.
机构信息
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Unit Number 1484, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Unit 1954, 1881 East Road, Houston, Texas 77054, USA.
出版信息
Cancer Cell. 2018 Apr 9;33(4):570-580. doi: 10.1016/j.ccell.2018.03.015.
Abstract
The microbiome is receiving significant attention given its influence on a host of human diseases including cancer. Its role in response to cancer treatment is becoming increasingly apparent, with evidence suggesting that modulating the gut microbiome may affect responses to numerous forms of cancer therapy. A working knowledge of the microbiome is vital as we move forward in this age of precision medicine, and an understanding of the microbiome's influence on immune responses and cancer is key. It is also important to understand factors influencing the gut microbiome and strategies to manipulate the microbiome to augment therapeutic responses.
摘要
鉴于微生物组对包括癌症在内的多种人类疾病的影响，它受到了广泛关注。它在癌症治疗反应中的作用正变得越来越明显，有证据表明，调节肠道微生物组可能会影响多种癌症治疗方法的反应。在精准医学时代，我们必须掌握微生物组的相关知识，了解微生物组对免疫反应和癌症的影响是关键。了解影响肠道微生物组的因素以及利用微生物组来增强治疗反应的策略也很重要。
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