Martins Paulo N, Edil Barish H, McNally Lacey, Battula Narendra R
Department of Surgery, Transplantation Institute, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
Department of Surgery, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA.
Artif Organs. 2025 Aug;49(8):1229-1235. doi: 10.1111/aor.15011. Epub 2025 Apr 22.
Machine perfusion preservation of grafts has become the gold standard organ preservation method. It has been developed to improve the quality of grafts due to the increasing gap between demand and supply of organs for transplantation. Following successful long-term machine perfusion preservation with automated commercial devices developed for preservation of organs for transplantation, there is increasing interest in utilizing perfused discarded human organs and xenografts for a variety of purposes beyond transplantation including gene therapy and modulation, drug testing, chemotherapy, ex vivo surgery, organ supporting systems, bioengineering, and surgical training and education. Here, we review all current and potential applications of machine perfusion preservation.
移植物的机器灌注保存已成为器官保存的金标准方法。由于移植器官供需差距日益增大，该方法得以发展以提高移植物质量。随着用于移植器官保存的自动化商用设备成功实现长期机器灌注保存，人们越来越有兴趣将灌注后的废弃人体器官和异种移植物用于移植以外的各种目的，包括基因治疗与调控、药物测试、化疗、体外手术、器官支持系统、生物工程以及外科培训与教育。在此，我们综述了机器灌注保存的所有当前及潜在应用。
