Xu Pan, Pan Chunduo, Yuan Minli, Zhu Ying, Wei Shanjie, Lu Hongyan, Zhang Wen
Department of Pediatrics, The Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China.
Department of Microbiology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.
Front Microbiol. 2025 Apr 7;16:1564755. doi: 10.3389/fmicb.2025.1564755. eCollection 2025.
Changes in the gut microbiome have been associated with the development of acute respiratory infection (ARI). However, due to methodological limitations, our knowledge of the gut virome in patients with ARIs remains limited.
In this study, fecal samples from children with ARI were investigated using viral metagenomics.
The fecal virome was analyzed, and several suspected disease-causing viruses were identified. The five viral families with the highest abundance of sequence reads were , , , , and . Additionally, human adenovirus, human bocavirus, human astrovirus, norovirus, and human rhinovirus were detected. The genome sequences of these viruses were respectively described, and phylogenetic trees were constructed using the gene sequences of the viruses.
We characterized the composition of gut virome in children with acute respiratory infections. However, further research is required to elucidate the relationship between acute respiratory infection and gut viruses.
肠道微生物群的变化与急性呼吸道感染（ARI）的发生有关。然而，由于方法学上的局限性，我们对ARI患者肠道病毒组的了解仍然有限。
在本研究中，使用病毒宏基因组学对ARI儿童的粪便样本进行了调查。
对粪便病毒组进行了分析，并鉴定出几种疑似致病病毒。序列读数丰度最高的五个病毒科分别是 、 、 、 和 。此外，还检测到人类腺病毒、人类博卡病毒、人类星状病毒、诺如病毒和人类鼻病毒。分别描述了这些病毒的基因组序列，并使用病毒的基因序列构建了系统发育树。
我们对急性呼吸道感染儿童的肠道病毒组组成进行了表征。然而，需要进一步研究以阐明急性呼吸道感染与肠道病毒之间的关系。
