Sun Yawen, Zhong Qiqi, Hou Yingci, Liu Xin, Yan Mingyue, Zhou Luolin, Liu Shiyi, Hong Senkai, He Jun
First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Front Neurol. 2025 Apr 7;16:1528340. doi: 10.3389/fneur.2025.1528340. eCollection 2025.
The incidence of acute ischemic stroke has been rising steadily in China and globally, with its high mortality and disability rates significantly affecting quality of life. As an important adjunct therapy, acupuncture has been widely implemented in stroke management. Emerging studies have investigated the effects of DU meridian and Chong Mai acupuncture on ischemic hemiparesis; however, the vascular protective mechanisms of electroacupuncture therapy targeting these meridians require further elucidation in stroke rehabilitation research.
This prospective cohort study aims to investigate the clinical efficacy and limitations of DU meridian acupuncture combined with Temporal Triple Needling (Sanjian) therapy in stroke rehabilitation. The intervention's therapeutic potential is evaluated through its modulatory effects on CD14+/CD14- monocyte subpopulations within peripheral blood mononuclear cells (PBMCs), with particular focus on angiogenesis-mediated vascular protection mechanisms.
Sixty-six patients with acute ischemic stroke will be randomly assigned 1:1 to control (conventional basal therapy, = 33) and acupuncture (conventional standard stroke care + acupuncture, = 33) groups for 10 days of intervention. The primary outcome is NIHSS score. The secondary outcomes: BMI and mRS scores, the level of TNF-A and IL-1B in serum, vascular endothelial growth factor (VEGF), Endocan ES, CD14+ and CD14- levels of peripheral blood mononuclear cells.
The aim of this study is to investigate whether electroacupuncture targeting the DU meridian combined with Temporal Triple Needling (Sanjian) improves cerebrovascular endothelial function in acute ischemic stroke patients, thereby reducing the NIHSS score and preventing further disease progression. This study also aims to contribute positively to the development of relevant clinical treatment protocols and to facilitate further research into the underlying mechanisms of these effects.
International Traditional Medicine Clinical Trial Registry ITMCTR2024000508.
在中国和全球范围内，急性缺血性中风的发病率一直在稳步上升，其高死亡率和致残率严重影响生活质量。作为一种重要的辅助治疗方法，针灸已在中风治疗中广泛应用。新兴研究探讨了督脉和冲脉针刺对缺血性偏瘫的影响；然而，针对这些经络的电针疗法在中风康复研究中的血管保护机制尚需进一步阐明。
本前瞻性队列研究旨在探讨督脉针刺联合颞三针疗法在中风康复中的临床疗效及局限性。通过评估其对外周血单个核细胞（PBMC）中CD14+/CD14-单核细胞亚群的调节作用来评价该干预措施的治疗潜力，特别关注血管生成介导的血管保护机制。
66例急性缺血性中风患者将按1:1随机分为对照组（常规基础治疗，n = 33）和针灸组（常规标准中风护理 + 针灸，n = 33），进行为期10天的干预。主要结局指标为美国国立卫生研究院卒中量表（NIHSS）评分。次要结局指标：体重指数（BMI）和改良Rankin量表（mRS）评分、血清中肿瘤坏死因子 - A（TNF - A）和白细胞介素 - 1β（IL - 1B）水平、血管内皮生长因子（VEGF）、内脂素（Endocan ES）、外周血单个核细胞的CD14+和CD14-水平。
本研究的目的是探讨针对督脉的电针联合颞三针是否能改善急性缺血性中风患者的脑血管内皮功能，从而降低NIHSS评分并防止疾病进一步进展。本研究还旨在为相关临床治疗方案的制定做出积极贡献，并促进对这些作用潜在机制的进一步研究。
国际传统医学临床试验注册中心ITMCTR2024000508 。
