Zuo Cheng, Shen Zi-Duo, Lu Yaojun
Department of Cardiology, Central Hospital of Baotou, Baotou, China.
Stroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2025 Apr 7;16:1521415. doi: 10.3389/fendo.2025.1521415. eCollection 2025.
is an anti-aging gene, and the α-klotho protein it encodes reportedly has cardiovascular protective effects. The atherogenic index of plasma (AIP) is a novel and comprehensive lipid index that correlates with atherosclerotic burden and is a critical risk factor for cardiovascular diseases. There are no studies examining the relationship between AIP and α-klotho; thus, we aimed to explore this potential association.
Data were extracted from the National Health and Nutrition Examination Survey 2007-2016 database, and the relationship between AIP and serum α-klotho levels was analyzed using weighted multivariate linear regression.
After adjusting for risk factors, AIP showed a significant negative correlation with the logarithm of serum α-klotho levels in women. The trend analysis and smoothed curve fitting showed a nonlinear dose-response relationship. Threshold effect analysis showed a significant difference in the association between AIP and α-klotho before and after the AIP break point (0.434). Subgroup analyses demonstrated that the negative association of AIP with α-klotho was consistent across subgroups. However, the correlation between AIP and serum α-klotho in men was not significant.
Our study provides new evidence for sex differences in the association between AIP and serum α-klotho levels.
α-klotho是一种抗衰老基因，据报道其编码的α-klotho蛋白具有心血管保护作用。血浆致动脉粥样硬化指数（AIP）是一种新的综合血脂指标，与动脉粥样硬化负担相关，是心血管疾病的关键危险因素。目前尚无关于AIP与α-klotho之间关系的研究；因此，我们旨在探讨这种潜在关联。
从2007 - 2016年国家健康与营养检查调查数据库中提取数据，并使用加权多元线性回归分析AIP与血清α-klotho水平之间的关系。
在调整危险因素后，AIP与女性血清α-klotho水平的对数呈显著负相关。趋势分析和平滑曲线拟合显示为非线性剂量反应关系。阈值效应分析显示，在AIP断点（0.434）前后，AIP与α-klotho之间的关联存在显著差异。亚组分析表明，AIP与α-klotho的负相关在各亚组中一致。然而，男性中AIP与血清α-klotho之间的相关性不显著。
我们的研究为AIP与血清α-klotho水平之间关联的性别差异提供了新证据。
