Lai Xiaoli, Chen Tao
Department of Endocrinology and Metabolism, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, 364000, China.
The Third Clinical Medical College of Fujian Medical University, Fujian Medical University, Longyan, 364000, China.
Sci Rep. 2024 Aug 8;14(1):18408. doi: 10.1038/s41598-024-69226-5.
Klotho, an anti-aging protein, is believed to participate in metabolic diseases and play a potential protective role by regulating insulin sensitivity. This study aimed to explore the relationship between the triglyceride-glucose (TyG) index (a simple marker of insulin resistance) and serum soluble Klotho (S-Klotho) levels. The cross-sectional study comprised 5237 adults aged 40-79 years who participated in the National Health and Nutrition Examination Surveys (NHANES) 2007-2016. The TyG index was calculated as ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. The serum levels of S-Klotho were measured by enzyme-linked immunosorbent assay. The association between the TyG index and S-Klotho levels was investigated by multiple linear regression models, smoothed curve fitting, segmented linear regression models, subgroup analyses, and interaction tests. The TyG index was inversely associated with serum S-Klotho level after full adjustment (β = - 45.11, 95% CI (- 79.53, - 10.69), P = 0.011). Furthermore, we also found a non-linear correlation and saturation phenomenon between the TyG index and serum S-Klotho levels, with a turning point of 9.56. In addition, a significant interaction effect of sex was found between the two (P for interaction < 0.001), with a more pronounced association observed in females. Further studies are required to explore the mechanisms and verify the correlation.
klotho是一种抗衰老蛋白，被认为参与代谢性疾病，并通过调节胰岛素敏感性发挥潜在的保护作用。本研究旨在探讨甘油三酯-葡萄糖（TyG）指数（一种简单的胰岛素抵抗标志物）与血清可溶性klotho（S-Klotho）水平之间的关系。这项横断面研究纳入了5237名年龄在40-79岁之间、参加了2007-2016年美国国家健康与营养检查调查（NHANES）的成年人。TyG指数的计算方法为ln[空腹甘油三酯（mg/dL）×空腹血糖（mg/dL）/2]。采用酶联免疫吸附测定法测量血清S-Klotho水平。通过多元线性回归模型、平滑曲线拟合、分段线性回归模型、亚组分析和交互作用检验，研究TyG指数与S-Klotho水平之间的关联。在进行全面调整后，TyG指数与血清S-Klotho水平呈负相关（β=-45.11，95%CI（-79.53，-10.69），P=0.011）。此外，我们还发现TyG指数与血清S-Klotho水平之间存在非线性相关性和饱和现象，转折点为9.56。此外，发现两者之间存在显著的性别交互作用（交互作用P<0.001），在女性中观察到的关联更为明显。需要进一步研究来探索其机制并验证这种相关性。
