Savides M C, Oehme F W, Leipold H W
Am J Vet Res. 1985 Jul;46(7):1485-9.
Oral N-acetylcysteine (NAC), IV NAC, and IV sodium sulfate were evaluated as treatments for cats dosed orally with toxic sublethal doses of acetaminophen (APAP). Six cats were given single oral doses of 120 mg of APAP/kg of body weight and the respective antidote at 4.5, 8.5, and 12.5 hours after APAP dosing in 3 separate trials. The cats were given each antidotal treatment in random order with at least 3 weeks separating the individual APAP-treated trials. Clinical signs, plasma APAP half-lives, clinical chemical values, and APAP urinary excretion and metabolites were studied. Results were compared (P less than 0.05) with each other and with those of a control group of 6 cats given identical APAP doses, but given no antidotal treatment. At the dosage levels used, oral NAC, IV NAC, and IV sodium sulfate were equally effective antidotes, as measured by decreased methemoglobinemia, increased whole blood reduced glutathione, decreased APAP half-lives, and increased urinary excretion of the APAP-sulfate conjugate. All the antidotal treatments produced results significantly different from those in the control cats.
口服N-乙酰半胱氨酸（NAC）、静脉注射NAC和静脉注射硫酸钠被评估为对口服毒性亚致死剂量对乙酰氨基酚（APAP）的猫的治疗方法。在3项独立试验中，6只猫分别口服120 mg APAP/kg体重的单次剂量，并在APAP给药后4.5、8.5和12.5小时给予相应的解毒剂。以随机顺序对猫进行每种解毒剂治疗，各次APAP治疗试验之间至少间隔3周。研究了临床症状、血浆APAP半衰期、临床化学值以及APAP的尿排泄和代谢产物。将结果相互比较（P<0.05），并与6只给予相同APAP剂量但未接受解毒剂治疗的对照组猫的结果进行比较。在所使用的剂量水平下，通过降低高铁血红蛋白血症、增加全血还原型谷胱甘肽、缩短APAP半衰期以及增加APAP-硫酸盐结合物的尿排泄来衡量，口服NAC、静脉注射NAC和静脉注射硫酸钠是同样有效的解毒剂。所有解毒剂治疗产生的结果与对照猫的结果有显著差异。
