St Omer V V, McKnight E D
J Am Vet Med Assoc. 1980 May 1;176(9):911-3.
Acute acetaminophen intoxication in the cat was studied to characterize the antidotal profile of acetylcysteine. Toxicosis was associated with cyanosis, hyperventilation, depression, and facial edema. Abnormal laboratory findings were methemoglobinemia and elevated serum glutamic-pyruvic transaminase activity. In one trial, each of ten cats was given a 325-mg tablet of acetaminophen, then another after 4 hours. Five of the cats were given antidotal treatment with acetylcysteine (140 mg/kg, per os) at the time of the second dosing with acetaminophen and at 8-hour intervals thereafter for a total of three treatments. All treated cats survived. Two of the untreated cats died. In another trial, doubling each dose of acetaminophen (650 mg) proved fatal in all of four untreated cats. When antidotal therapy was initiated at the time of the second dosing with acetaminophen and repeated at 8- or 4-hour intervals for three treatments, two of four cats in each treatment group survived. Although antidotal therapy was associated with a return of serum glutamic-pyruvic transaminase and methemoglobinemia values toward normal, only the methemoglobin value was a reliable prognostic indicator.
对猫急性对乙酰氨基酚中毒进行了研究，以确定乙酰半胱氨酸的解毒特性。中毒与发绀、换气过度、抑郁和面部水肿有关。实验室异常发现为高铁血红蛋白血症和血清谷丙转氨酶活性升高。在一项试验中，给10只猫每只服用一片325毫克的对乙酰氨基酚，4小时后再服一片。其中5只猫在第二次服用对乙酰氨基酚时给予乙酰半胱氨酸解毒治疗（140毫克/千克，口服），此后每隔8小时治疗一次，共治疗三次。所有接受治疗的猫均存活。两只未治疗的猫死亡。在另一项试验中，将对乙酰氨基酚的剂量加倍（650毫克），结果发现所有4只未治疗的猫均死亡。当在第二次服用对乙酰氨基酚时开始解毒治疗，并每隔8小时或4小时重复治疗三次时，每个治疗组的4只猫中有2只存活。虽然解毒治疗使血清谷丙转氨酶和高铁血红蛋白血症值恢复正常，但只有高铁血红蛋白值是可靠的预后指标。
