Alqattan Mohmmad H, Alqadhi Mukhtar A, Alawadh Ali M, Almajed Mohammed A, Albakheet Salman S, Aldandan Ali W
Radiology and Nuclear Medicine, Al-Ahsa Health Cluster, Al-Ahsa, SAU.
Pathology, Al-Ahsa Health Cluster, Al-Ahsa, SAU.
Cureus. 2025 Mar 22;17(3):e80998. doi: 10.7759/cureus.80998. eCollection 2025 Mar.
Graves' disease, an autoimmune disorder characterized by diffuse goiter and hyperthyroidism, is commonly associated with bilateral thyroid involvement. However, unilateral Graves' disease is an extremely rare entity. Additionally, patients with Graves' disease have an increased risk of thyroid malignancy, particularly papillary thyroid carcinoma (PTC), which often presents with aggressive histological features. This case highlights the rare occurrence of unilateral Graves' disease with ipsilateral papillary thyroid carcinoma, emphasizing the importance of careful diagnostic assessment, including imaging and fine needle aspiration (FNA), in patients with atypical presentations. To the best of our knowledge, this is the third reported case of unilateral Graves' disease with ipsilateral thyroid malignancy and the first case documented in Saudi Arabia.
格雷夫斯病是一种以弥漫性甲状腺肿和甲状腺功能亢进为特征的自身免疫性疾病，通常与双侧甲状腺受累有关。然而，单侧格雷夫斯病是一种极其罕见的情况。此外，格雷夫斯病患者发生甲状腺恶性肿瘤的风险增加，尤其是乳头状甲状腺癌（PTC），其通常表现出侵袭性组织学特征。本病例突出了单侧格雷夫斯病合并同侧乳头状甲状腺癌的罕见情况，强调了对非典型表现患者进行仔细诊断评估的重要性，包括影像学检查和细针穿刺抽吸活检（FNA）。据我们所知，这是第三例报道的单侧格雷夫斯病合并同侧甲状腺恶性肿瘤的病例，也是沙特阿拉伯记录的首例。
