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同步放化疗治疗不可切除的眼睑鳞状细胞癌

An Unresectable Eyelid Squamous Cell Carcinoma Treated With Concurrent Chemoradiation Therapy.

作者信息

Ohara Kenzo, Izumiya Yuto, Inoue Takahiro, Kumai Takumi, Takahara Miki

机构信息

Department of Otolaryngology, Head and Neck Surgery, Asahikawa Medical University, Asahikawa, JPN.

出版信息

Cureus. 2025 Mar 22;17(3):e80984. doi: 10.7759/cureus.80984. eCollection 2025 Mar.

DOI:10.7759/cureus.80984
PMID:40260346
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12011349/
Abstract

Cases of advanced eyelid squamous cell carcinoma (ESCC) are rare because most patients with eyelid cancer visit hospitals when the cancer is in relatively early stages. However, utill date, no study has recommended the most suitable treatment method for unresectable advanced skin squamous cell carcinoma (SSCC). Herein, we report a case of unresectable ESCC that invaded the orbital contents and paranasal sinuses, and was treated with moderate-dose cisplatin and docetaxel chemotherapy with radiation therapy. Our treatment method may be a feasible option for patients with advanced SSCC.

摘要

晚期眼睑鳞状细胞癌（ESCC）病例较为罕见，因为大多数眼睑癌患者在癌症处于相对早期阶段时就会前往医院就诊。然而，迄今为止，尚无研究推荐出针对无法切除的晚期皮肤鳞状细胞癌（SSCC）最合适的治疗方法。在此，我们报告一例侵犯眼眶内容物和鼻窦的无法切除的ESCC病例，该病例接受了中等剂量顺铂和多西他赛化疗联合放射治疗。我们的治疗方法可能是晚期SSCC患者的一种可行选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/6e341e236922/cureus-0017-00000080984-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/dd81887a5c2f/cureus-0017-00000080984-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/f18713c2dbc8/cureus-0017-00000080984-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/76c3b62593fc/cureus-0017-00000080984-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/6e341e236922/cureus-0017-00000080984-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/dd81887a5c2f/cureus-0017-00000080984-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/f18713c2dbc8/cureus-0017-00000080984-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/76c3b62593fc/cureus-0017-00000080984-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff5f/12011349/6e341e236922/cureus-0017-00000080984-i04.jpg

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本文引用的文献

1
Squamous cell carcinoma of the eyelid.眼睑鳞状细胞癌。
Jpn J Clin Oncol. 2024 Jan 7;54(1):4-12. doi: 10.1093/jjco/hyad127.
2
Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation.头颈部癌症患者中多西他赛作为放射增敏剂的 III 期随机试验结果，不适合顺铂为基础的放化疗。
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术后头颈部癌症每周顺铂加放疗（JCOG1008）：一项多中心、非劣效性、II/III 期随机对照临床试验。
J Clin Oncol. 2022 Jun 20;40(18):1980-1990. doi: 10.1200/JCO.21.01293. Epub 2022 Mar 1.
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Concurrent chemoradiotherapy with cisplatin and docetaxel for head and neck squamous cell carcinoma.顺铂和多西他赛同步放化疗治疗头颈部鳞状细胞癌
Clin Otolaryngol. 2022 Jan;47(1):228-233. doi: 10.1111/coa.13876. Epub 2021 Oct 26.
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Nasopharyngeal carcinoma.鼻咽癌。
Lancet. 2019 Jul 6;394(10192):64-80. doi: 10.1016/S0140-6736(19)30956-0. Epub 2019 Jun 6.
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Non-melanoma skin cancer: United Kingdom National Multidisciplinary Guidelines.非黑色素瘤皮肤癌：英国国家多学科指南
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Impact of cisplatin dose intensity on human papillomavirus-related and -unrelated locally advanced head and neck squamous cell carcinoma.顺铂剂量强度对人乳头瘤病毒相关和不相关的局部晚期头颈部鳞状细胞癌的影响。
Eur J Cancer. 2016 Nov;67:174-182. doi: 10.1016/j.ejca.2016.08.013. Epub 2016 Sep 24.
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