Kim Jina, Wee Chan Woo, Lee Chang Geol, Keum Ki Chang, Kim Kyung Hwan
Department of Radiation Oncology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
Head Neck. 2025 Sep;47(9):2522-2530. doi: 10.1002/hed.28170. Epub 2025 Apr 22.
Determining whether to treat the elective cervical lymph node (LN) area remains a dilemma in maxillary sinus squamous cell carcinoma (SCC). This study analyzed the patterns of initial LN involvement and recurrence to guide treatment strategies.
We retrospectively reviewed 119 patients with maxillary sinus SCC treated between 2005 and 2023. Patients received definitive concurrent chemoradiotherapy, neoadjuvant therapy followed by local treatment, or upfront surgery with or without adjuvant radiotherapy.
Among 119 patients, 28 (23.5%) had clinical LN involvement at diagnosis, primarily at ipsilateral neck levels I and II. Regional failure occurred in 18 (19.8%) cN0 and 9 (32.1%) cN+ patients, with ipsilateral level II being the most common site. Contralateral failures were frequent in cN+ patients. Distant metastases occurred in 17 patients (14.3%), predominantly in the lungs.
Understanding LN involvement and recurrence patterns can refine radiation field design and follow-up strategies in maxillary sinus SCC.
在上颌窦鳞状细胞癌（SCC）中，决定是否治疗选择性颈部淋巴结（LN）区域仍然是一个难题。本研究分析了初始LN受累和复发模式，以指导治疗策略。
我们回顾性分析了2005年至2023年间接受治疗的119例上颌窦SCC患者。患者接受了确定性同步放化疗、新辅助治疗后行局部治疗，或先行手术并辅以或不辅以放疗。
119例患者中，28例（23.5%）在诊断时存在临床LN受累，主要位于同侧颈部I区和II区。18例（19.8%）cN0和9例（32.1%）cN+患者发生区域失败，同侧II区是最常见的部位。cN+患者对侧失败很常见。17例患者（14.3%）发生远处转移，主要转移至肺部。
了解LN受累和复发模式可以优化上颌窦SCC的放疗野设计和随访策略。
