Massot C, Guyot M A, Blanchard A, Norberciak L, Donze C
Service de Médecine Physique et de Réadaptation, 249 rue du Grand But, 59462 Lomme Cedex, France.
ETHICS, (EA7446), Université Catholique de Lille, FLSH, Lille, France.
NeuroRehabilitation. 2025 Mar;56(2):243-253. doi: 10.1177/10538135241306674. Epub 2025 Feb 20.
BackgroundPatients with Multiple Sclerosis (PwMS) have gait disorders. The efficiency of treadmill training on walking distance is debatable.ObjectiveThis study evaluated the efficacy of a 6-week treadmill training program at heart rate at the first ventilatory threshold (HR) on walking distance compared with a control group in PwMS.MethodsThis prospective, multicenter study included 46 PwMS with moderate disability which randomized into training group (TG) and control group (CG). Patients performed cardiopulmonary exercise test to determine HR. TG realized walking treadmill training program at HR: 18 sessions (3 sessions/week) over 6 weeks. The distance on the six-minute walk test (6MWT), Timed 25 foot walk, patient-reported walking ability, berg balance scale, fatigue scale, the HR at the end of the 6MWT (HR) were collected at baseline, 6 weeks and 12 weeks.ResultsThe 6MWT distance showed a significant overall group effect (30.6 m; 95%CI = (6.6; 54.6); = 0.017). The perceived impact of walking was significantly decreased in the TG (-6.1; 95% CI = (-9.2; -2.9); p = 0.0006). No correlation was found between HR and HR.ConclusionAerobic treadmill training significantly enhanced walking distance and reduced perceived walking difficulties in PwMS.
背景
多发性硬化症患者（PwMS）存在步态障碍。跑步机训练对步行距离的效果存在争议。
目的
本研究评估了与对照组相比，为期6周的以第一通气阈值心率（HR）进行跑步机训练计划对PwMS患者步行距离的疗效。
方法
这项前瞻性、多中心研究纳入了46例中度残疾的PwMS患者，随机分为训练组（TG）和对照组（CG）。患者进行心肺运动测试以确定HR。TG在HR水平进行跑步机步行训练计划：6周内进行18次训练（每周3次）。在基线、6周和12周时收集6分钟步行试验（6MWT）的距离、25英尺定时步行、患者报告的步行能力、伯格平衡量表、疲劳量表、6MWT结束时的HR（HR）。
结果
6MWT距离显示出显著的总体组效应（30.6米；95%CI =（6.6；54.6）； = 0.017）。TG组中步行的感知影响显著降低（-6.1；95%CI =（-9.2；-2.9）；p = = 0.0006）。未发现HR与HR之间存在相关性。
结论
有氧跑步机训练显著增加了PwMS患者的步行距离，并减少了其感知到的步行困难。
