Zhang Yifan, Li Gen, Su Hao, Liang Yin, Lv Yuanyuan, Yu Laikang
Beijing Key Laboratory of Sports Performance and Skill Assessment, Beijing Sport University, Beijing, China.
Department of Strength and Conditioning Assessment and Monitoring, Beijing Sport University, Beijing, China.
J Neurol. 2025 May 18;272(6):405. doi: 10.1007/s00415-025-13129-6.
This systematic review and meta-analysis aimed to evaluate the effect of exercise on balance function in multiple sclerosis (MS) patients and identify the optimal exercise prescription for this population.
A comprehensive search was conducted across PubMed, Web of Science, EBSCO, Cochrane, and Scopus up to February 21, 2025. The data were pooled using weighted mean differences (WMD) and 95% confidence interval.
Fifty-two studies fulfilled the inclusion criteria. Exercise significantly improved Berg balance scale (BBS; WMD, 4.03; p < 0.00001) and timed up and go test (TUG; WMD, -1.01; p < 0.00001) in MS patients. The subgroup analyses revealed that resistance exercise (WMD, 6.07; p = 0.004), interventions lasting ≥ 8 weeks (WMD, 4.24; p < 0.00001), ≥ 3 times per week (WMD, 4.57; p < 0.00001), ≥ 60 min per session (WMD, 4.36; p < 0.00001), ≥ 180 min per week (WMD, 4.41; p < 0.00001) were most effective in improving BBS. Greater improvements were observed in patients aged < 45 years (WMD, 4.57; p < 0.00001) and those with baseline EDSS > 3.5 (WMD, 3.97; p < 0.00001).
Exercise was found to improve balance in MS patients. Our results suggest that MS patients may benefit from engaging in exercise sessions at least three times per week, with each session lasting 60 min or more, for a minimum duration of 8 weeks. Achieving a weekly exercise goal of 180 min or more may further enhance balance function.
本系统评价和荟萃分析旨在评估运动对多发性硬化症（MS）患者平衡功能的影响，并确定该人群的最佳运动处方。
截至2025年2月21日，在PubMed、科学网、EBSCO、Cochrane和Scopus数据库中进行了全面检索。使用加权平均差（WMD）和95%置信区间对数据进行汇总。
52项研究符合纳入标准。运动显著改善了MS患者的伯格平衡量表（BBS；WMD，4.03；p＜0.00001）和计时起立行走测试（TUG；WMD，-1.01；p＜0.00001）。亚组分析显示，抗阻运动（WMD，6.07；p = 0.004）、持续时间≥8周的干预措施（WMD，4.24；p＜0.00001）、每周≥3次（WMD，4.57；p＜0.00001）、每次≥60分钟（WMD，4.36；p＜0.00001）、每周≥180分钟（WMD，4.41；p＜0.00001）在改善BBS方面最有效。在年龄＜45岁的患者（WMD，4.57；p＜0.00001）和基线扩展残疾状态量表（EDSS）＞3.5的患者中观察到更大的改善（WMD，3.97；p＜0.00001）。
发现运动可改善MS患者的平衡功能。我们的结果表明，MS患者可能受益于每周至少进行三次运动，每次运动持续60分钟或更长时间，最短持续8周。实现每周180分钟或更长时间的运动目标可能会进一步增强平衡功能。
