Steenwyk Jacob L, Loucks Jeffrey T, Buida Thomas J
Howard Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, United States.
Independent Researcher, Durham, NC 27707, United States.
Nucleic Acids Res. 2025 Jul 7;53(W1):W169-W171. doi: 10.1093/nar/gkaf325.
Multiple sequence alignment trimming can help improve phylogenetic signal and reduce computational load. ClipKIT trims multiple sequence alignments by retaining phylogenetically informative sites and removing all others. Here, we present a web browser application for ClipKIT, which supports DNA, protein, and codon data types in FASTA format. The web browser application can process one or many multiple sequence alignment files, which users can subsequently download. Users can also view the trimmed multiple sequence alignment using a web-based multiple sequence alignment viewer. ClipKIT is available at https://clipkit.genomelybio.com, is free and open to all users, and there is no login requirement. ClipKIT in the browser aims to broaden the accessibility of web-based tools for phylogenetics research.
多序列比对修剪有助于提高系统发育信号并减少计算量。ClipKIT通过保留系统发育信息位点并去除所有其他位点来修剪多序列比对。在此，我们展示了一个用于ClipKIT的网络浏览器应用程序，它支持FASTA格式的DNA、蛋白质和密码子数据类型。该网络浏览器应用程序可以处理一个或多个多序列比对文件，用户随后可以下载这些文件。用户还可以使用基于网络的多序列比对查看器来查看修剪后的多序列比对。ClipKIT可在https://clipkit.genomelybio.com获取，免费向所有用户开放，无需登录。浏览器中的ClipKIT旨在扩大基于网络的系统发育研究工具的可及性。
