Kumar Pranav, Buckley Jenni, Roddy Edward, Thomas Martin J
School of Medicine, Keele University, Staffordshire, UK.
School of Allied Health Professions and Pharmacy, Keele University, Staffordshire, UK.
Musculoskeletal Care. 2025 Jun;23(2):e70103. doi: 10.1002/msc.70103.
Gout is the most common form of inflammatory arthritis. It is predominantly managed with pharmacological interventions, and physical impairments in people with gout have seldom been studied. We aimed to identify gout-related physical impairments that may be targeted by physical interventions.
Five electronic databases (Medline, AMED, EMBASE, APA PsycInfo, CINAHL) were searched from inception to April 2024, together with reference lists of all included articles. We included all study designs, except for singular case reports, conducted in people with gout, where at least one objective physical impairment outcome was reported. All title, abstract and full-text article eligibility screening was performed independently by two reviewers. Independent data extraction included design and setting, participant demographics, baseline characteristics, disease duration, physical impairment investigated, and method of assessment. Data synthesis was summarised descriptively.
Twenty-four articles were included. Most studies were cross-sectional designs in secondary care settings, 11 were performed in New Zealand. Participants' mean ages ranged from 41.3 (standard deviation (SD) not calculated) to 75.8 (SD 5.2) years. Participants were predominantly male. Gout duration ranged from 24 h to a mean of 28 years. Five broad categories of physical impairment were identified: lower extremity function, joint range of motion, strength, deformity, and Achilles tendon stiffness.
Based on limited evidence, the most commonly observed physical impairments are related to lower extremity function and joint range of motion. Our review identifies the need to better understand and quantify gout-related physical impairments before developing targeted physical interventions.
痛风是炎症性关节炎最常见的形式。其主要通过药物干预进行治疗，而痛风患者的身体损伤很少被研究。我们旨在确定可能通过物理干预来解决的痛风相关身体损伤。
检索了五个电子数据库（Medline、AMED、EMBASE、APA PsycInfo、CINAHL），时间跨度从建库至2024年4月，并检索了所有纳入文章的参考文献列表。我们纳入了所有在痛风患者中进行的研究设计，但不包括单一病例报告，这些研究至少报告了一项客观的身体损伤结果。两名审稿人独立进行所有标题、摘要和全文文章的合格性筛选。独立的数据提取包括设计和设置、参与者人口统计学、基线特征、疾病持续时间、所研究的身体损伤以及评估方法。数据综合采用描述性总结。
纳入了24篇文章。大多数研究是在二级医疗机构进行的横断面设计，其中11项在新西兰进行。参与者的平均年龄范围为41.3岁（未计算标准差）至75.8岁（标准差5.2）。参与者以男性为主。痛风持续时间从24小时到平均28年不等。确定了五大类身体损伤：下肢功能、关节活动范围、力量、畸形和跟腱僵硬。
基于有限的证据，最常观察到的身体损伤与下肢功能和关节活动范围有关。我们的综述表明，在制定有针对性的物理干预措施之前，需要更好地理解和量化痛风相关的身体损伤。
