Moore G R, Neumann P E, Suzuki K, Lijtmaer H N, Traugott U, Raine C S
Ann Neurol. 1985 Jun;17(6):604-11. doi: 10.1002/ana.410170614.
A 54-year-old woman with a four-month history of progressive neurological illness was found at postmortem examination to have lesions of Balo's concentric sclerosis. Balo lesions were found in several areas scattered widely throughout the central nervous system, including the spinal cord, a previously unreported location, and were studied by histological and ultrastructural methods. Balo lesions consisted of bands of intact myelin alternating with zones of demyelination. These lesions were centered on a perivascular cuff of inflammatory cells. The center of the lesion was the oldest area with the concentric rings of demyelination decreasing in age with increasing distance from the center. The bands of intact myelin comprised mainly remyelinated fibers, were similar to those seen at the edges of chronic active multiple sclerosis plaques, and may have represented the repaired margins of preceding episodes. The occurrence of small foci of acute demyelination centered on perivascular cuffs and other changes typical of both acute and chronic active multiple sclerosis may indicate that the lesion of Balo's concentric sclerosis represents an intermediate stage in the development of an established multiple sclerosis lesion.
一名患有进行性神经疾病四个月的54岁女性在尸检时被发现患有巴洛同心性硬化病变。在整个中枢神经系统广泛分布的几个区域发现了巴洛病变，包括脊髓（一个此前未报告过的部位），并采用组织学和超微结构方法进行了研究。巴洛病变由完整髓鞘带与脱髓鞘区域交替组成。这些病变以炎症细胞的血管周围套袖为中心。病变中心是最古老的区域，同心性脱髓鞘环随着距中心距离的增加而年龄递减。完整髓鞘带主要由再髓鞘化纤维组成，类似于在慢性活动性多发性硬化斑块边缘所见，可能代表先前发作的修复边缘。以血管周围套袖为中心的急性脱髓鞘小病灶的出现以及急性和慢性活动性多发性硬化的其他典型变化可能表明，巴洛同心性硬化病变代表了已确诊的多发性硬化病变发展过程中的一个中间阶段。
