Dreha-Kulaczewski Steffi F, Helms Gunther, Dechent Peter, Hofer Sabine, Gärtner Jutta, Frahm Jens
Department of Pediatrics and Pediatric Neurology, Georg August University, Göttingen, Germany.
Neuroradiology. 2009 Feb;51(2):113-21. doi: 10.1007/s00234-008-0470-y. Epub 2008 Oct 29.
Proton magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) yield different parameters for characterizing the evolution of a demyelinating white matter disease. The purpose was to elucidate biochemical and microstructural changes in Balo's concentric sclerosis lesions and to correlate the findings with the clinical course.
Localized short-echo time MRS and DTI were performed over 6 years in a left occipital lesion of a female patient (age at onset 13.8 years) with Balo's concentric sclerosis. A right homonym hemianopsia persisted.
Metabolite patterns were in line with initial active demyelination followed by gliosis and partial recovery of neuroaxonal metabolites. Fractional anisotropy and mean diffusivity of tissue water remained severely altered. Fiber tracking confirmed a disruption in the geniculo-calcarine tract as well as involvement of the corpus callosum.
MRS and DTI depict complementary parameters, but DTI seems to correlate better with clinical symptoms.
质子磁共振波谱（MRS）和扩散张量成像（DTI）在表征脱髓鞘性白质疾病的演变过程中会产生不同的参数。目的是阐明巴洛同心圆性硬化病变中的生化和微观结构变化，并将这些发现与临床病程相关联。
对一名患有巴洛同心圆性硬化的女性患者（发病年龄13.8岁）的左侧枕叶病变进行了为期6年的局部短回波时间MRS和DTI检查。右侧同向偏盲持续存在。
代谢物模式与最初的活动性脱髓鞘相符，随后是胶质增生以及神经轴突代谢物的部分恢复。组织水的分数各向异性和平均扩散率仍严重改变。纤维束追踪证实了膝状体-距状束中断以及胼胝体受累。
MRS和DTI描绘了互补的参数，但DTI似乎与临床症状的相关性更好。
