Berezhinskaia V V, Egorenko G G, Dolgova G V, Svinogeeva T P, Berezina E K
Antibiot Med Biotekhnol. 1985 May;30(5):355-60.
The general toxic and organotropic properties of amikacin were studied in acute and chronic experiments. The antibiotic was administered to the experimental animals in the doses equivalent to the therapeutic ones for humans or exceeding them 2-3 times. No unfavourable effect of amikacin in the above doses on hearing was observed. A certain increase in the level of urea nitrogen in the blood serum and leukopenia were registered only after administration of the highest drug dose exceeding 2 times the equivalent treatment dose of amikacin for humans (15 g). After the use of this dose separate microfocal necrotic lesions were detected morphologically in the proximal tubules of the kidneys. The lesions were of a transitory nature. It is concluded that amikacin has a wide range of therapeutic doses and the level of its safety is rather high.
在急性和慢性实验中研究了阿米卡星的一般毒性和器官亲和性。以相当于人类治疗剂量或超过其2 - 3倍的剂量给实验动物施用该抗生素。未观察到上述剂量的阿米卡星对听力有不利影响。仅在给予超过人类等效治疗剂量（15g）2倍的最高药物剂量后，才记录到血清尿素氮水平有一定升高和白细胞减少。使用该剂量后，在肾脏近端小管中形态学上检测到单独的微灶性坏死病变。这些病变是暂时的。结论是阿米卡星有广泛的治疗剂量范围，其安全性相当高。
