Egorenko G G, Berezina E K, Berezhinskaia V V, Dolgova G V, Kovalenko L P
Antibiotiki. 1983 Sep;28(9):678-82.
General toxic and organotropic properties of sisomicin sulfate were studied in chronic experiments on different animal species with the use of doses equivalent to therapeutic ones in humans or exceeding them by several times. When sisomicin was injected intramuscularly for 4 weeks in a dose equivalent by the body surface to the average daily dose for humans, no significant effect on the macroorganism was observed. When the dose was 2--4 times higher, a significant increase in the blood serum levels of the urea nitrogen, creatinine, bilirubin and aspartate aminotransferase was shown. Histological examinations revealed focal adiposis of epithelial cells of the convoluted tubules of the kidney and small areas of parenchymal necrosis. Impairment of vestibular and auditory functions was detected in some animals.
在慢性实验中，使用相当于人类治疗剂量或超过该剂量数倍的剂量，对不同动物物种研究了硫酸西索米星的一般毒性和器官亲和性特性。当以按体表面积相当于人类平均日剂量的剂量肌肉注射西索米星4周时，未观察到对整体机体有显著影响。当剂量高2至4倍时，血清中尿素氮、肌酐、胆红素和天冬氨酸转氨酶水平显著升高。组织学检查显示，肾曲管上皮细胞有局灶性脂肪变性以及小面积实质坏死。在一些动物中检测到前庭和听觉功能受损。
