总状毛霉中可诱导的表型多药耐药性。
Inducible phenotypic multidrug resistance in the fungus Mucor racemosus.
作者信息
Leathers T D, Sypherd P S
出版信息
Antimicrob Agents Chemother. 1985 Jun;27(6):892-6. doi: 10.1128/AAC.27.6.892.
Abstract
The dimorphic fungus Mucor racemosus exhibited a single-step, inducible resistance to cycloheximide, trichodermin, and amphotericin B. Cells adapted to inhibitory levels of the antibiotics after 12 to 40 h. The adaptation involved all the cells in the population and was not the result of the selection of resistant mutants. Adaptation to one drug provided cross resistance to other, dissimilar drugs. Resistance was lost within several generations of growth in the absence of the inhibitors.
摘要
丝状真菌总状毛霉对放线菌酮、木霉素和两性霉素B表现出一步诱导抗性。细胞在12至40小时后适应抗生素的抑制水平。这种适应涉及群体中的所有细胞，并非抗性突变体选择的结果。对一种药物的适应赋予了对其他不同药物的交叉抗性。在没有抑制剂的情况下生长几代后，抗性消失。
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