• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Concentrations of fusidic acid, cloxacillin, and cefamandole in sera and atrial appendages of patients undergoing cardiac surgery.心脏手术患者血清和心耳中夫西地酸、氯唑西林和头孢孟多的浓度。
Antimicrob Agents Chemother. 1985 Jun;27(6):928-32. doi: 10.1128/AAC.27.6.928.
2
Penetration of ceforanide and cefamandole into the right atrial appendage, pericardial fluid, sternum, and intercostal muscle of patients undergoing open heart surgery.头孢乙腈和头孢孟多在接受心脏直视手术患者的右心耳、心包液、胸骨和肋间肌中的渗透情况。
Antimicrob Agents Chemother. 1982 Mar;21(3):416-20. doi: 10.1128/AAC.21.3.416.
3
Concentration and bactericidal activity of fusidic acid and cloxacillin in serum and synovial fluid.
J Antimicrob Chemother. 1999 Apr;43(4):593-6. doi: 10.1093/jac/43.4.593.
4
Comparative study of cefamandole versus ampicillin plus cloxacillin: prophylactic antibiotics in cardiac surgery.头孢孟多与氨苄西林加氯唑西林的对比研究：心脏手术中的预防性抗生素
Ann Thorac Surg. 1982 Feb;33(2):152-8. doi: 10.1016/s0003-4975(10)61902-9.
5
Cefonicid concentrations in serum and atrial tissue during open-heart surgery.心脏直视手术期间血清和心房组织中的头孢尼西浓度。
Antimicrob Agents Chemother. 1983 May;23(5):790-2. doi: 10.1128/AAC.23.5.790.
6
[Plasma and tissue concentrations of cefamandole during cardiac surgery].
Ann Fr Anesth Reanim. 1989;8(4):316-20. doi: 10.1016/S0750-7658(89)80072-3.
7
Cefamandole and isoxazolyl penicillins in antibiotic prophylaxis of patients undergoing total hip or knee-joint arthroplasty.
Arch Orthop Trauma Surg (1978). 1988;107(4):228-30. doi: 10.1007/BF00449674.
8
Penetration characteristics of cefamandole into the right atrial appendage and pericardial fluid in patients undergoing open-heart surgery.
Ann Thorac Surg. 1980 Feb;29(2):104-8. doi: 10.1016/s0003-4975(10)61644-x.
9
Pharmacokinetics of fusidic acid and cefepime in heart tissues: implications for a role in surgical prophylaxis.
J Chemother. 2008 Aug;20(4):468-71. doi: 10.1179/joc.2008.20.4.468.
10
Penetration of penicillins into cardiac valves and auricles of patients undergoing open-heart surgery.
Scand J Thorac Cardiovasc Surg. 1985;19(1):49-53. doi: 10.3109/14017438509102821.

引用本文的文献

1
Pharmacokinetics of intravenous fusidic acid in patients with cholestasis.胆汁淤积患者静脉注射夫西地酸的药代动力学
Antimicrob Agents Chemother. 1993 Mar;37(3):501-6. doi: 10.1128/AAC.37.3.501.
2
In vitro activities of ceftriaxone and fusidic acid against 13 isolates of Coxiella burnetii, determined using the shell vial assay.采用空斑试验测定头孢曲松和夫西地酸对13株贝氏柯克斯体的体外活性。
Antimicrob Agents Chemother. 1993 Mar;37(3):491-4. doi: 10.1128/AAC.37.3.491.
3
Antibiotic activity in serum following single and repeated oral administration of sodium fusidate in volunteers.志愿者单次及重复口服夫西地酸钠后血清中的抗生素活性。
Eur J Drug Metab Pharmacokinet. 1994 Oct-Dec;19(4):337-41. doi: 10.1007/BF03188860.
4
Antimicrobial prophylaxis of experimental endocarditis caused by Staphylococcus epidermidis.表皮葡萄球菌所致实验性心内膜炎的抗菌预防
Infection. 1989 Mar-Apr;17(2):90-6. doi: 10.1007/BF01646884.
5
Concentrations of teicoplanin in serum and atrial appendages of patients undergoing cardiac surgery.心脏手术患者血清和心耳中替考拉宁的浓度。
Antimicrob Agents Chemother. 1990 Sep;34(9):1699-702. doi: 10.1128/AAC.34.9.1699.

本文引用的文献

1
Fucidin: a new orally active antibiotic.梭链孢酸：一种新型口服活性抗生素。
Lancet. 1962 May 5;1(7236):928-31. doi: 10.1016/s0140-6736(62)91968-2.
2
Investigations on the flucloxacillin levels in human serum, lung tissue, pericardial fluid and heart tissue.
Int J Clin Pharmacol Ther Toxicol. 1980 Sep;18(9):405-11.
3
Concentrations of cefamandole and cefsulodin in serum, heart valves, subcutaneous tissue, and muscle of patients undergoing open-heart surgery.接受心脏直视手术患者血清、心脏瓣膜、皮下组织及肌肉中头孢孟多和头孢磺啶的浓度。
J Infect Dis. 1980 Aug;142(2):290. doi: 10.1093/infdis/142.2.290.
4
Comparison of antimicrobial susceptibility patterns among coagulase-negative staphylococci.凝固酶阴性葡萄球菌抗菌药敏模式的比较
Antimicrob Agents Chemother. 1982 Mar;21(3):436-40. doi: 10.1128/AAC.21.3.436.
5
Prosthetic valve endocarditis.人工瓣膜心内膜炎
J Thorac Cardiovasc Surg. 1980 Jul;80(1):31-7.
6
Penetration characteristics of cefamandole into the right atrial appendage and pericardial fluid in patients undergoing open-heart surgery.
Ann Thorac Surg. 1980 Feb;29(2):104-8. doi: 10.1016/s0003-4975(10)61644-x.
7
Antimicrobial susceptibilities of coagulase-negative staphylococci isolated from urinary infections.从尿路感染中分离出的凝固酶阴性葡萄球菌的抗菌药敏性
Antimicrob Agents Chemother. 1983 May;23(5):793-5. doi: 10.1128/AAC.23.5.793.
8
Staphylococcus epidermidis causing prosthetic valve endocarditis: microbiologic and clinical observations as guides to therapy.引起人工瓣膜心内膜炎的表皮葡萄球菌：微生物学和临床观察作为治疗指南
Ann Intern Med. 1983 Apr;98(4):447-55. doi: 10.7326/0003-4819-98-4-447.
9
Comparative study of cefamandole versus ampicillin plus cloxacillin: prophylactic antibiotics in cardiac surgery.头孢孟多与氨苄西林加氯唑西林的对比研究：心脏手术中的预防性抗生素
Ann Thorac Surg. 1982 Feb;33(2):152-8. doi: 10.1016/s0003-4975(10)61902-9.
10
In vitro susceptibility patterns of methicillin-resistant and-susceptible Staphylococcus auerues strains in a population of parenteral drug abusers from 1972 to 1981.1972年至1981年期间，对一群静脉注射药物滥用者中的耐甲氧西林和甲氧西林敏感金黄色葡萄球菌菌株进行的体外药敏模式研究。
Antimicrob Agents Chemother. 1983 Mar;23(3):450-7. doi: 10.1128/AAC.23.3.450.

心脏手术患者血清和心耳中夫西地酸、氯唑西林和头孢孟多的浓度。

Concentrations of fusidic acid, cloxacillin, and cefamandole in sera and atrial appendages of patients undergoing cardiac surgery.

作者信息

Bergeron M G, Desaulniers D, Lessard C, Lemieux M, Després J P, Métras J, Raymond G, Brochu G

出版信息

Antimicrob Agents Chemother. 1985 Jun;27(6):928-32. doi: 10.1128/AAC.27.6.928.

DOI:10.1128/AAC.27.6.928
PMID:4026265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC180189/
Abstract

The concentrations of cefamandole, cloxacillin and fusicid acid were measured in the serum and heart tissue of 100 recipients of these drugs before cardiac surgery. During cardiopulmonary bypass, mean (+/- standard deviation) peak concentrations in serum of all patients were 63.0 +/- 34.0 micrograms of cefamandole per ml, 30.8 +/- 17.7 micrograms of cloxacillin per ml, and 32.4 +/- 10.8 micrograms of fusidic acid per ml. Mean (+/- standard deviation) concentrations in atrial appendages taken 1 h (+/- 15 min) after infusion were 21.3 +/- 11.0 micrograms of cefamandole per g, 23.8 +/- 17.3 micrograms of cloxacillin per g, and 10.7 +/- 4.2 micrograms of fusidic acid per g. No cloxacillin could be detected in 5 of 39 heart specimens. Mean tissue-to-serum ratios at 1 h for cefamandole, cloxacillin, and fusidic acid were respectively 0.35, 0.73, and 0.33. Fusidic acid, a drug which is highly effective in vitro against both methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis, was detectable in heart tissue in concentrations which were 12 times higher than the MICs of this agent against these resistant microorganisms.

摘要

在100例心脏手术前接受这些药物治疗的患者的血清和心脏组织中，测定了头孢孟多、氯唑西林和夫西地酸的浓度。在体外循环期间，所有患者血清中的平均（±标准差）峰值浓度分别为每毫升63.0±34.0微克头孢孟多、每毫升30.8±17.7微克氯唑西林和每毫升32.4±10.8微克夫西地酸。输注后1小时（±15分钟）采集的心耳中的平均（±标准差）浓度分别为每克21.3±11.0微克头孢孟多、每克23.8±17.3微克氯唑西林和每克10.7±4.2微克夫西地酸。在39份心脏标本中有5份未检测到氯唑西林。头孢孟多、氯唑西林和夫西地酸在1小时时的平均组织与血清比值分别为0.35、0.73和0.33。夫西地酸是一种在体外对耐甲氧西林金黄色葡萄球菌和表皮葡萄球菌均高度有效的药物，在心脏组织中可检测到其浓度比该药物对这些耐药微生物的最低抑菌浓度高12倍。