Bergeron M G, Saginur R, Desaulniers D, Trottier S, Goldstein W, Foucault P, Lessard C
Laboratoire et Service d'Infectiologie, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Quebec, Canada.
Antimicrob Agents Chemother. 1990 Sep;34(9):1699-702. doi: 10.1128/AAC.34.9.1699.
The concentrations of teicoplanin in sera and heart tissues of 49 patients undergoing coronary bypass were measured. Each patient received a 6- or 12-mg/kg dose of teicoplanin administered in a slow intravenous bolus injection over 3 to 5 min beginning at the time of induction of anesthesia. Mean +/- standard error of the mean concentrations in serum were, for the two doses, respectively, 58.1 +/- 1.7 and 123.3 +/- 7.4 micrograms/ml 5 min after administration and 22.2 +/- 0.7 and 56.5 +/- 2.8 micrograms/ml at the time of removal of atrial appendages. Mean +/- standard error of the mean concentrations in tissue were 70.6 +/- 1.7 and 139.8 +/- 2.2 micrograms/g, respectively, giving mean tissue/serum ratios of 3.7 +/- 0.3 and 2.8 +/- 0.2, respectively. Teicoplanin penetrates heart tissue readily and reaches levels in the serum far in excess of the MICs for most pathogens that have been found to cause infections following open heart surgery.
对49例接受冠状动脉搭桥手术的患者血清和心脏组织中的替考拉宁浓度进行了测定。每位患者在麻醉诱导时开始，在3至5分钟内通过缓慢静脉推注给予6或12mg/kg剂量的替考拉宁。给药后5分钟，两剂量组血清中平均浓度±平均标准误分别为58.1±1.7和123.3±7.4μg/ml，在切除心耳时分别为22.2±0.7和56.5±2.8μg/ml。组织中平均浓度±平均标准误分别为70.6±1.7和139.8±2.2μg/g，组织/血清平均比值分别为3.7±0.3和2.8±0.2。替考拉宁易于穿透心脏组织，血清中达到的水平远远超过已发现的大多数导致心脏直视手术后感染的病原体的最低抑菌浓度。
