Joseph Davey Dvora, de Voux Alex, Shaetonhodi Natalie, Marks Michael, Frigati Lisa, Kufa Tendesayi
University of California Los Angeles, Los Angeles, USA.
Division of Epidemiology & Biostatistics, School of Public Health, University of Cape Town, Cape Town, South Africa.
Curr HIV/AIDS Rep. 2025 Apr 23;22(1):30. doi: 10.1007/s11904-025-00739-y.
There is an urgent need to improve interventions for HIV and syphilis in pregnancy to achieve elimination.
The tenets of vertical transmission strategies for HIV and syphilis overlap but have varying success due to differences in their transmission dynamics, diagnoses, and treatment. Key principles include prevention of maternal infection, screening and diagnosis early and throughout antenatal care, curative treatment (syphilis), viral load suppression (HIV), early infant diagnosis and treatment (HIV and congenital syphilis). We recommend improved guidelines, provider training and focused research and surveillance, including implementation studies to align HIV and syphilis screening and treatment during pregnancy. Opportunities to integrate syphilis screening and treatment into antenatal and HIV care enable providers to offer comprehensive maternal care.
Integrated HIV/syphilis services ensure a cohesive and person-centered approach, improving health outcomes through streamlined, efficient, and family-centered care pathways. We recommend key interventions to reduce HIV and syphilis in pregnancy and prevent vertical transmission.
迫切需要改进孕期艾滋病毒和梅毒的干预措施以实现消除目标。
艾滋病毒和梅毒垂直传播策略的原则相互重叠，但由于其传播动态、诊断和治疗方面的差异，成效各不相同。关键原则包括预防孕产妇感染、在整个产前护理期间尽早进行筛查和诊断、治愈性治疗（梅毒）、抑制病毒载量（艾滋病毒）、早期婴儿诊断和治疗（艾滋病毒和先天性梅毒）。我们建议改进指南、对医疗服务提供者进行培训并开展重点研究和监测，包括开展实施研究以协调孕期艾滋病毒和梅毒的筛查及治疗。将梅毒筛查和治疗纳入产前护理及艾滋病毒护理的机会，使医疗服务提供者能够提供全面的孕产妇护理。
综合艾滋病毒/梅毒服务确保了一种连贯且以人为本的方法，通过简化、高效且以家庭为中心的护理途径改善健康结局。我们建议采取关键干预措施以减少孕期艾滋病毒和梅毒感染并预防垂直传播。
