一项由护士主导的、基于理论的妇科癌症患者心理教育干预项目：一项多中心随机对照试验。

A nurse-led theory-based psycho-educational intervention programme for women with gynaecological cancer: a multicentre randomised controlled trial.

作者信息

Chow Ka Ming, Luo Guizhen, Chan Carmen W H, Choi Kai Chow, Chair Sek Ying, Shi Zeya, Leung Alice W Y

机构信息

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.

Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Hunan Province, 61 Jiefang West Road, Changsha, China.

出版信息

Support Care Cancer. 2025 Apr 22;33(5):405. doi: 10.1007/s00520-025-09460-3.

DOI:10.1007/s00520-025-09460-3

PMID:40263175

Abstract

PURPOSE

To explore the effects of a nurse-led psycho-educational interventions (PEI) on uncertainty in illness, anxiety and sexual functioning among women with gynaecological cancer (GC).

METHODS

An assessor-blinded multicentre randomised controlled trial was conducted in Hong Kong and Hunan, China. The intervention group received a 4-session, 12-week-long nurse-led PEI while the control group received attention on four occasions. The outcomes were measured at baseline and upon completion of the programme.

RESULTS

Of the 402 participants recruited, 202 were randomly assigned to the intervention group and 200 to the control group. The intervention demonstrated significant effects on ambiguity (GroupTime regression coefficient, B = - 2.13, 95% CI: - 3.87 to - 0.38, p = 0.017), inconsistency (GroupTime, B = - 1.27, 95% CI: - 2.19 to - 0.34, p = 0.007) and overall uncertainty in illness (Group*Time, B = - 3.27, 95% CI: - 6.34 to - 0.20, p = 0.037). At post-intervention, women in the intervention group were more likely to perceive a greater level of intimacy (p < 0.001), a greater level of sexual interest (p = 0.023) and their partners to have a greater interest in sexual relations (p = 0.005); and less likely to report a reduction in close physical contact with family and close friends (p = 0.034), when compared with their control counterparts.

CONCLUSION

We demonstrated the potential benefits of a nurse-led PEI on improving uncertainty in illness and sexual function among women with GC in China, in comparison to usual care. In view of the potential benefits of the PEI on uncertainty in illness and sexual functioning, the intervention could be incorporated into routine clinical practice.

TRIAL REGISTRATION

ISRCTN Registry (registration number: ISRCTN18351717, registered on 22 April 2023).

摘要

目的

探讨由护士主导的心理教育干预（PEI）对妇科癌症（GC）女性患者疾病不确定感、焦虑及性功能的影响。

方法

在中国香港和湖南进行了一项评估者盲法多中心随机对照试验。干预组接受为期4节、共12周的护士主导的PEI，而对照组接受4次关注。在基线和项目结束时测量结果。

结果

在招募的402名参与者中，202名被随机分配到干预组，200名被分配到对照组。干预对模糊性（组时间回归系数，B = -2.13，95%CI：-3.87至-0.38，p = 0.017）、不一致性（组时间，B = -1.27，95%CI：-2.19至-0.34，p = 0.007）和疾病总体不确定感（组*时间，B = -3.27，95%CI：-6.34至-0.20，p = 0.037）有显著影响。干预后，与对照组相比，干预组女性更有可能感知到更高水平的亲密感（p < 0.001）、更高水平的性兴趣（p = 0.023）以及伴侣对性关系有更高兴趣（p = 0.005）；且不太可能报告与家人和亲密朋友的亲密身体接触减少（p = 0.034）。