Cohen S R
Arch Dermatol. 1985 Aug;121(8):1022-7.
Workers engaged in a molded plastics operation were studied to determine the etiology of yellow staining reactions involving the skin, nails, and hair. A walk-through survey of the facility, medical interviews, physical examinations, and blood and urine tests were performed. 4,4'-Methylenedianiline (MDA), a component chemical of the manufacturing process, produced intense yellow discoloration of nitrocellulose paper in the laboratory and appeared to volatilize readily under ambient conditions. Thirty-five (65%) of 54 process workers showed varying degrees of staining while 11 workers employed in other parts of the factory showed no staining. Yellow staining was restricted to areas of the body where direct contact with MDA appeared likely. Laboratory studies did not provide evidence of systemic toxic effect. Because MDA is a known hepatotoxin for man, with carcinogenic properties in animal test systems, it is important to recognize yellow staining as a cutaneous marker of exposure to this chemical.
对从事模塑塑料作业的工人进行了研究，以确定涉及皮肤、指甲和头发的黄色染色反应的病因。对该设施进行了巡查、进行了医学访谈、体格检查以及血液和尿液检测。4,4'-亚甲基二苯胺（MDA）是制造过程中的一种成分化学物质，在实验室中可使硝化纤维素纸产生强烈的黄色变色，并且在环境条件下似乎易于挥发。54名生产工人中有35名（65%）表现出不同程度的染色，而在工厂其他部门工作的11名工人未出现染色。黄色染色仅限于身体上似乎可能直接接触MDA的部位。实验室研究未提供全身毒性作用的证据。由于MDA是一种已知的人类肝毒素，在动物试验系统中具有致癌特性，因此将黄色染色识别为接触这种化学物质的皮肤标志物很重要。
