Ji Juanjuan, Zhou Zhi, Zhu Yaling, Wang Rui, Liu Yali
School and Hospital of Stomatology, Kunming Medical University, 1088 Middle Haiyuan Road, High-Tech Zone, Kunming, 650106, Yunnan Province, China.
The Second People's hospital of Yunnan, 176 Qingnian Road, Kunming, Yunnan, China.
Sci Rep. 2025 Apr 22;15(1):13872. doi: 10.1038/s41598-025-98800-8.
Orthodontic treatment can enhance occlusal force, yet it may increase the sensitivity of periodontal tissues. To compare the impacts of orthodontic treatment, intervention, and combined treatment (intervention first, then orthodontics) on alveolar bone remodeling, we established a rat model with low occlusal function. Three weeks after combined treatment, the levels of BMP2 and BGP increased by approximately 36% and 78% respectively, and the changes were even more remarkable after 4 weeks. Meanwhile, the expression of CTSK was inhibited, while the expression of OPN and RUNX2 increased. From the second to the third week, the key proteins in the SIRT1/β - catenin pathway underwent changes. At 4 weeks, the expression of SIRT1 and β - catenin increased by around 73% and 60% respectively. This study indicates that the combined treatment alleviates the side effects of orthodontics. Orthodontic force may activate the β-catenin pathway via SIRT1 to balance alveolar bone osteogenesis and osteoclast differentiation. This research provides a targeted treatment strategy and a theoretical basis for treating teeth with low occlusal function. It will contribute to optimizing clinical treatment outcomes, reducing the risk of periodontal tissue damage, and improving the prognosis of orthodontic treatment for patients.
正畸治疗可增强咬合力，但可能会增加牙周组织的敏感性。为比较正畸治疗、干预治疗以及联合治疗（先干预治疗，再进行正畸治疗）对牙槽骨重塑的影响，我们建立了低咬合力功能的大鼠模型。联合治疗三周后，BMP2和BGP水平分别升高了约36%和78%，四周后变化更为显著。同时，CTSK的表达受到抑制，而OPN和RUNX2的表达增加。从第二周到第三周，SIRT1/β-连环蛋白通路中的关键蛋白发生了变化。在四周时，SIRT1和β-连环蛋白的表达分别增加了约73%和60%。本研究表明，联合治疗减轻了正畸治疗的副作用。正畸力可能通过SIRT1激活β-连环蛋白通路，以平衡牙槽骨的成骨作用和破骨细胞分化。本研究为治疗低咬合力功能牙齿提供了靶向治疗策略和理论依据。它将有助于优化临床治疗效果，降低牙周组织损伤风险，并改善患者正畸治疗的预后。
